|Renal impairment caused by chronic occupational chromate exposure|
|Wang, TC; Jia, GA; Zhang, J; Ma, YH; Feng, WY; Liu, LZ; Zhang, N; Yan, L; Wang, X; Zhang, XY; Liu, ZH; Du, XM; Zhen, S; Feng WY(丰伟悦)
|发表期刊||INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
; Yan, Lei
; Wang, Xiang
; Zhang, Xueyan
; Liu, Zihong
; Du, Xianmei
; Zhen, Sen] Peking Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
; [Wang, Tiancheng] Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China
; [Zhang, Ji
; Ma, Yanhui
; Liu, Lanzheng
; Zhang, Ning] Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China
; [Feng, Weiyue] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci, Beijing, Peoples R China
|摘要||To determine the nephritic toxicity of chromate after chronic occupational exposure. The environmental contamination was assessed by measuring the chromium (Cr) in 8-h airborne sampler. The integrated level of Cr was determined by Cr concentrations in the whole blood (WB-Cr) and the urine (U-Cr). The renal glomerular and tubule impairment was evaluated by determination of cystatin C (Cys-C) in the serum and microalbumin (mALB), urinary beta(2)-microglobulin (beta(2)M), N-acetyl-beta-d-glucosaminidase (NAG) activity in the urine. The mean occupational exposure time to Cr was 12.86 years with average daily air level of 27.13 mu g/m(3) comparing to 0.11 mu g/m(3) of the background level. The WB-Cr and U-Cr were 23.49 mu g/L and 17.41 mu g/g creatinine (Cre), respectively in the chromate-exposed workers comparing to 3.32 mu g/L and 1.52 mu g/g Cre in the controls. The serum Cys-C and urinary mALB were significantly increased in the chromate-exposed workers. Exposure to Cr seems to induce an enhanced level of urinary NAG activity and beta(2)M concentration. The increased serum Cys-C concentration was positively correlated with the level of serum Cre. The U-Cr was positively correlated to the concentrations of urinary mALB, beta(2)M, and the activity of NAG. Chronic occupational exposure to chromate causes comprehensive renal impairment though more severity could occur in the tubule than in the glomeruler.|
|学科领域||Public, Environmental & Occupational Health
|WOS研究方向||Public, Environmental & Occupational Health
|WOS类目||Public, Environmental & Occupational Health
Wang, TC,Jia, GA,Zhang, J,et al. Renal impairment caused by chronic occupational chromate exposure[J]. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH,2011,84(4):393-401.
Wang, TC.,Jia, GA.,Zhang, J.,Ma, YH.,Feng, WY.,...&丰伟悦.(2011).Renal impairment caused by chronic occupational chromate exposure.INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH,84(4),393-401.
Wang, TC,et al."Renal impairment caused by chronic occupational chromate exposure".INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 84.4(2011):393-401.