IHEP OpenIR  > 多学科研究中心
Brain glucose metabolic changes in patients with chronic pain due to brachial plexus avulsion: A positron emission tomography study
其他题名臂丛神经撕脱伤后慢性疼痛患者脑区葡萄糖代谢的研究
Chen, FY; Tao, W; Cheng, X; Zhou, K; Shan, BC; Yuan, XL; Hu, YS; Mang, XH; Li, YJ; Dan BC(单保慈); Yuan XL(袁秀丽)
2008
发表期刊PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
卷号35期号:4页码:387-392
通讯作者[Chen Fu-Yong ; Tao Wei ; Hu Yong-Sheng ; Mang Xiao-Hua ; Li Yong-Jie] Capital Med Univ, Xuanwu Hosp, Beijing Inst Funct Neurosurg, Beijing 100053, Peoples R China ; [Cheng Xin] Peking Union Med Coll, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China ; [Zhou Ke] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China ; [Shan Bao-Ci ; Yuan Xiu-Li] Chinese Acad Sci, Inst High Energy Phys, Nucl Anal Lab, Beijing 100853, Peoples R China
文章类型Article
摘要Chronic pain due to brachial plexus avulsion (BPA) is a kind of refractory neuropathic pain, yet there is a lack of knowledge regarding underlying brain activity. To further identify brain regions involved in chronic pain due to BPA, fluorine-18 fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) was used to observe brain glucose metabolic changes in those patients. Five patients with chronic pain due to left-BPA, whose pain reduced more than 75% after dorsal root entry zoneotomy (DREZotomy) were selected. The visual analog scale (VAS), Hamilton depression scale, Hamilton anxiety scale and F-18-FDG PET of brain were recorded before and 14 days after DREZotomy respectively. Statistical parametric mapping 2 (SPM2) was applied for data analysis. Comparing with PET during pain before DREZotomy, PET after DREZotomy showed significant glucose metabolism decreases in bilateral caudate, orbitofrontal cortex (OFC) (BA 11), contralateral subgenual cingulate (BA25) and ipsilateral dorsolateral prefrontal cortex (DLPFC) (BA46/47), and significant glucose metabolism increases in contralateral thalamus, pulvinar and ipsilateral parietal lobe (BA7). The results suggested that the brain areas involved in emotion, attention and internal modulation of pain play an important role in the modulation of chronic pain due to BPA.
关键词neuropathic pain positron emission tomography brachial plexus avulsion prefrontal cortex thalamus orbitofrontal cortex
学科领域Biochemistry & Molecular Biology; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Biochemistry & Molecular Biology ; Biophysics
URL查看原文
语种英语
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000255316400005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/237273
专题多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Chen, FY,Tao, W,Cheng, X,et al. Brain glucose metabolic changes in patients with chronic pain due to brachial plexus avulsion: A positron emission tomography study[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2008,35(4):387-392.
APA Chen, FY.,Tao, W.,Cheng, X.,Zhou, K.,Shan, BC.,...&袁秀丽.(2008).Brain glucose metabolic changes in patients with chronic pain due to brachial plexus avulsion: A positron emission tomography study.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,35(4),387-392.
MLA Chen, FY,et al."Brain glucose metabolic changes in patients with chronic pain due to brachial plexus avulsion: A positron emission tomography study".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 35.4(2008):387-392.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
3664.pdf(206KB)期刊论文作者接受稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, FY]的文章
[Tao, W]的文章
[Cheng, X]的文章
百度学术
百度学术中相似的文章
[Chen, FY]的文章
[Tao, W]的文章
[Cheng, X]的文章
必应学术
必应学术中相似的文章
[Chen, FY]的文章
[Tao, W]的文章
[Cheng, X]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。