Bio-distribution and metabolic paths of silica coated CdSeS quantum dots
Chen Z(陈真); Meng H(孟幻); Xing GM(邢更妹); Gao XY(高学云); Sun BY(孙宝云); Yuan H(袁慧); Zhang CC(张程程); Zhao F(赵峰); Zhao YL(赵宇亮); Chen, Z; Chen, H; Meng, H; Xing, GM; Gao, XY; Sun, BY; Shi, XL; Yuan, H; Zhang, CC; Liu, R; Zhao, F; Zhao, YL; Fang, XH
刊名TOXICOLOGY AND APPLIED PHARMACOLOGY
2008
卷号230期号:3页码:364-371
关键词quantum dot bio-kinetics metabolic path nanoparticle ICP-MS
学科分类Pharmacology & Pharmacy; Toxicology
DOI10.1016/j.taap.2008.03.022
通讯作者[Chen, Zhen ; Meng, Huan ; Xing, Gengmei ; Gao, Xueyun ; Sun, Baoyun ; Yuan, Hui ; Zhang, Chengcheng ; Zhao, Feng ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Zhao, Yuliang] Natl Ctr Nanosci & Technol China, Beijing 100080, Peoples R China ; [Chen, Hu] Guizhou Normal Univ, Inst S China Karst, Guiyang 550001, Peoples R China ; [Shi, Xiaoli ; Fang, Xiaohong] Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China ; [Chen, Zhen ; Meng, Huan ; Shi, Xiaoli ; Zhang, Chengcheng ; Liu, Ru ; Zhao, Yuliang] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
文章类型Article
英文摘要With the rapid development of quantum dot (QD) technology, water-soluble QDs have the prospect of being used as a biological probe for specific diagnoses, but their biological behaviors in vivo are little known. Our recent in vivo studies concentrated on the bio-kinetics of QDs coated by hydroxyl group modified silica networks (the QDs are 21.3 +/- 2.0 nm in diameter and have maximal emission at 570 nm). Male ICR mice were intravenously given the water-soluble QDs with a single dose of 5 nmol/mouse. Inductively coupled plasma-mass spectrometry was used to measure the Cd-111 content to indicate the concentration of QDs in plasma, organs, and excretion samples collected at predetermined time intervals. Meanwhile, the distribution and aggregation state of QDs in tissues were also investigated by pathological examination and differential centrifugation. The plasma half-life and clearance of QDs were 19.8 +/- 3.2 h and 57.3 +/- 9.2 ml/h/kg, respectively. The liver and kidney were the main target organs for QDs. The QDs metabolized in three paths depending on their distinct aggregated states in vivo. A fraction of free QDs, maintaining their original form, could be filtered by glomerular capillaries and excreted via urine as small molecules within five days. Most QDs bound to protein and aggregated into larger particles that were metabolized in the liver and excreted via feces in vivo. After five days, 8.6% of the injected dose of aggregated QDs still remained in hepatic tissue and it was difficult for this fraction to clear. (C) 2008 Published by Elsevier Inc.
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
原文出处查看原文
语种英语
WOS记录号WOS:000258412200014
引用统计
被引频次:110[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/237173
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_粒子天体物理中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Chen Z,Meng H,Xing GM,et al. Bio-distribution and metabolic paths of silica coated CdSeS quantum dots[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2008,230(3):364-371.
APA 陈真.,孟幻.,邢更妹.,高学云.,孙宝云.,...&Fang, XH.(2008).Bio-distribution and metabolic paths of silica coated CdSeS quantum dots.TOXICOLOGY AND APPLIED PHARMACOLOGY,230(3),364-371.
MLA 陈真,et al."Bio-distribution and metabolic paths of silica coated CdSeS quantum dots".TOXICOLOGY AND APPLIED PHARMACOLOGY 230.3(2008):364-371.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
3493.pdf(1256KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[陈真]的文章
[孟幻]的文章
[邢更妹]的文章
百度学术
百度学术中相似的文章
[陈真]的文章
[孟幻]的文章
[邢更妹]的文章
必应学术
必应学术中相似的文章
[陈真]的文章
[孟幻]的文章
[邢更妹]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 3493.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。