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Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes
Yan L(晏亮); Zhao F(赵峰); Zhao YL(赵宇亮); Yan, LA; Zhao, F; Li, SJ; Hu, ZB; Zhao, YL
2011
发表期刊NANOSCALE
卷号3期号:2页码:362-382
通讯作者[Yan, Liang ; Zhao, Feng ; Zhao, Yuliang] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Li, Shoujian ; Zhao, Yuliang] Sichuan Univ, Coll Chem & Chem Engn, Chengdu 610064, Peoples R China ; [Hu, Zhongbo ; Zhao, Yuliang] Chinese Acad Sci, Grad Univ, Coll Mat Sci, Beijing 100049, Peoples R China
文章类型Article
摘要The toxicity grade for a bulk material can be approximately determined by three factors (chemical composition, dose, and exposure route). However, for a nanomaterial it depends on more than ten factors. Interestingly, some nano-factors (like huge surface adsorbability, small size, etc.) that endow nanomaterials with new biomedical functions are also potential causes leading to toxicity or damage to the living organism. Is it possible to create safe nanomaterials if such a number of complicated factors need to be regulated? We herein try to find answers to this important question. We first discuss chemical processes that are applicable for nanosurface modifications, in order to improve biocompatibility, regulate ADME, and reduce the toxicity of carbon nanomaterials (carbon nanotubes, fullerenes, metallofullerenes, and graphenes). Then the biological/toxicological effects of surface-modified and unmodified carbon nanomaterials are comparatively discussed from two aspects: the lowered toxic responses or the enhanced biomedical functions. We summarize the eight biggest challenges in creating low-toxicity and safer nanomaterials and some significant topics of future research needs: to find out safer nanofactors; to establish controllable surface modifications and simpler chemistries for low-toxic nanomaterials; to explore the nanotoxicity mechanisms; to justify the validity of current toxicological theories in nanotoxicology; to create standardized nanomaterials for toxicity tests; to build theoretical models for cellular and molecular interactions of nanoparticles; and to establish systematical knowledge frameworks for nanotoxicology.
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
DOI10.1039/c0nr00647e
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语种英语
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000287363500003
引用统计
被引频次:151[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/237161
专题多学科研究中心
加速器中心
作者单位中国科学院高能物理研究所
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Yan L,Zhao F,Zhao YL,et al. Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes[J]. NANOSCALE,2011,3(2):362-382.
APA 晏亮.,赵峰.,赵宇亮.,Yan, LA.,Zhao, F.,...&Zhao, YL.(2011).Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes.NANOSCALE,3(2),362-382.
MLA 晏亮,et al."Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes".NANOSCALE 3.2(2011):362-382.
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