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Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats
He X(何潇); Zhang ZY(张智勇); Zhang HF(张海凤); Zhao YL(赵宇亮); Chai ZF(柴之芳); He, X; Zhang, ZY; Zhang, HF; Zhao, YL; Chai, ZF
2008
Source PublicationTOXICOLOGICAL SCIENCES
Volume103Issue:2Pages:354-361
Corresponding Author[He, Xiao ; Zhang, Zhiyong ; Zhang, Haifeng ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [He, Xiao ; Zhang, Zhiyong ; Zhang, Haifeng ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China ; [Zhang, Haifeng ; Zhao, Yuliang] Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Chai, Zhifang] Shenzhen Univ, Inst Nucl Technol, Shenzhen 518060, Peoples R China
SubtypeArticle
AbstractWith their widespread application in industry, agriculture, medicine, and daily life, rare earth elements (REEs) are widely used in various fields and eventually accumulated in human body. Therefore, understanding the effects of REEs on health has become more and more important. In this work, the neurotoxicity of lanthanum (La) was evaluated. Wistar rats were exposed to lanthanum chloride through oral administration at 0, 0.1, 2, and 40 mg/kg doses from gestation day 0 through 6 months of age. Experiments were carried out to reveal the effects of La exposure on brain functions from four aspects including behavioral performance, [Ca2+](i) level and the activity of Ca2+-ATPase (adenosine triphosphatase) in hippocampal cells, oxidative stress, and Nissl staining. Adverse effects were observed in 2 and 40 mg/kg dose groups and increased with dose. Morris water maze test showed that La exposure at 2 and 40 mg/kg could significantly impair the behavioral performance. (The preference for the target quadrant decreased by 16.6% and 19.4% versus control, respectively.) The neurotoxicological consequences demonstrated that the alteration in homeostasis of [Ca2+](i)/Ca2+-ATPase (the ratio of [Ca2+](i) vs. Ca2+-ATPase activity increased by 44% in rats of 40 mg/kg group), the inhibition to activities of antioxidant enzymes, and the subsequent cell damage (18% and 23% cell loss in CA3 subregion of rats in 2 and 40 mg/kg group, respectively) might be involved in the neurological adverse effects of REEs exposure.
Keywordintracellular free calcium lanthanum Morris water maze Nissl staining oxidative stress rare earth elements
Subject AreaToxicology
DOI10.1093/toxsci/kfn046
URL查看原文
Language英语
WOS Research AreaToxicology
WOS SubjectToxicology
WOS IDWOS:000255760800013
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/237112
Collection院士
多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
He X,Zhang ZY,Zhang HF,et al. Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats[J]. TOXICOLOGICAL SCIENCES,2008,103(2):354-361.
APA 何潇.,张智勇.,张海凤.,赵宇亮.,柴之芳.,...&Chai, ZF.(2008).Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats.TOXICOLOGICAL SCIENCES,103(2),354-361.
MLA 何潇,et al."Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats".TOXICOLOGICAL SCIENCES 103.2(2008):354-361.
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