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Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats
He X(何潇); Zhang ZY(张智勇); Zhang HF(张海凤); Zhao YL(赵宇亮); Chai ZF(柴之芳); He, X; Zhang, ZY; Zhang, HF; Zhao, YL; Chai, ZF
刊名TOXICOLOGICAL SCIENCES
2008
卷号103期号:2页码:354-361
关键词intracellular free calcium lanthanum Morris water maze Nissl staining oxidative stress rare earth elements
学科分类Toxicology
DOI10.1093/toxsci/kfn046
通讯作者[He, Xiao ; Zhang, Zhiyong ; Zhang, Haifeng ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [He, Xiao ; Zhang, Zhiyong ; Zhang, Haifeng ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China ; [Zhang, Haifeng ; Zhao, Yuliang] Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Chai, Zhifang] Shenzhen Univ, Inst Nucl Technol, Shenzhen 518060, Peoples R China
文章类型Article
英文摘要With their widespread application in industry, agriculture, medicine, and daily life, rare earth elements (REEs) are widely used in various fields and eventually accumulated in human body. Therefore, understanding the effects of REEs on health has become more and more important. In this work, the neurotoxicity of lanthanum (La) was evaluated. Wistar rats were exposed to lanthanum chloride through oral administration at 0, 0.1, 2, and 40 mg/kg doses from gestation day 0 through 6 months of age. Experiments were carried out to reveal the effects of La exposure on brain functions from four aspects including behavioral performance, [Ca2+](i) level and the activity of Ca2+-ATPase (adenosine triphosphatase) in hippocampal cells, oxidative stress, and Nissl staining. Adverse effects were observed in 2 and 40 mg/kg dose groups and increased with dose. Morris water maze test showed that La exposure at 2 and 40 mg/kg could significantly impair the behavioral performance. (The preference for the target quadrant decreased by 16.6% and 19.4% versus control, respectively.) The neurotoxicological consequences demonstrated that the alteration in homeostasis of [Ca2+](i)/Ca2+-ATPase (the ratio of [Ca2+](i) vs. Ca2+-ATPase activity increased by 44% in rats of 40 mg/kg group), the inhibition to activities of antioxidant enzymes, and the subsequent cell damage (18% and 23% cell loss in CA3 subregion of rats in 2 and 40 mg/kg group, respectively) might be involved in the neurological adverse effects of REEs exposure.
类目[WOS]Toxicology
研究领域[WOS]Toxicology
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语种英语
WOS记录号WOS:000255760800013
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被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/237112
专题院士_期刊论文
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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He X,Zhang ZY,Zhang HF,et al. Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats[J]. TOXICOLOGICAL SCIENCES,2008,103(2):354-361.
APA 何潇.,张智勇.,张海凤.,赵宇亮.,柴之芳.,...&Chai, ZF.(2008).Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats.TOXICOLOGICAL SCIENCES,103(2),354-361.
MLA 何潇,et al."Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats".TOXICOLOGICAL SCIENCES 103.2(2008):354-361.
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