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Particokinetics and Extrapulmonary Translocation of Intratracheally Instilled Ferric Oxide Nanoparticles in Rats and the Potential Health Risk Assessment
Zhu MT(朱墨桃); Feng WY(丰伟悦); Wang Y(王云); Wang B(汪冰); Wang M(王萌); Ou YH(欧阳宏); Zhao YL(赵宇亮); Chai ZF(柴之芳); Zhu, MT; Feng, WY; Wang, Y; Wang, B; Wang, M; Ouyang, H; Zhao, YL; Chai, ZF
2009
发表期刊TOXICOLOGICAL SCIENCES
卷号107期号:2页码:342-351
通讯作者[Zhu, Mo-Tao ; Feng, Wei-Yue ; Wang, Yun ; Wang, Bing ; Wang, Meng ; Ouyang, Hong ; Zhao, Yu-Liang ; Chai, Zhi-Fang] Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Zhu, Mo-Tao ; Feng, Wei-Yue ; Wang, Yun ; Wang, Bing ; Wang, Meng ; Ouyang, Hong ; Zhao, Yu-Liang ; Chai, Zhi-Fang] Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Zhu, Mo-Tao ; Wang, Yun] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
文章类型Article
摘要Exposure to nanoparticles has presented potential risks to human cardiorespiratory systems. Pulmonary retention and extrapulmonary redistribution of inhaled nanoparticles have been considered to be important contributing factors of cardiorespiratory diseases. In the present work, 22-nm (59)Fe(2)O(3) nanoparticles (radioactive isotope (59)Fe-labeled ferric oxide nanoparticles) were intratracheally instilled into the male Sprague-Dawley rats at a dose of 4 mg/rat. Extrapulmonary distribution of (59)Fe(2)O(3) in organs and its metabolism in lung, blood, urine, and feces were measured for 50 days of exposure. Phagocytosis and clearance of agglomerated nano-Fe(2)O(3) by monocytes/macrophages were observed by histopathology and inductively coupled plasma-mass spectrometry examination. Our results showed intratracheal-instilled nano-(59)Fe(2)O(3) could pass through the alveolar-capillary barrier into systemic circulation within 10 min that consisted with one-compartment kinetic model. The nano-(59)Fe(2)O(3) in the lung was distributed to organs rich in mononuclear phagocytes, including liver, spleen, kidney and testicle. The plasma elimination half-life of nano-(59)Fe(2)O(3) was 22.8 days and the lung clearance rate was 3.06 mu g/day, indicating the systemic accumulation and lung retention had occurred. The deposited nano-Fe(2)O(3) in interstitial lung was probably contributed by the particles escaping from alveolar macrophages phagocytosis and macrophages clearance function overloading. Our results suggest that the effect of Fe(2)O(3) nanoparticles exposure, even at low concentration, should be assessed because of the potential lung and systemic cumulative toxicity of the nanoparticles.
学科领域Toxicology
研究领域[WOS]Toxicology ; Toxicology
DOI10.1093/toxsci/kfn245
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语种英语
研究领域[WOS]Toxicology ; Toxicology
WOS类目Toxicology
WOS记录号WOS:000262723000005
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被引频次:124[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/237063
专题院士
加速器中心
多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Zhu MT,Feng WY,Wang Y,et al. Particokinetics and Extrapulmonary Translocation of Intratracheally Instilled Ferric Oxide Nanoparticles in Rats and the Potential Health Risk Assessment[J]. TOXICOLOGICAL SCIENCES,2009,107(2):342-351.
APA 朱墨桃.,丰伟悦.,王云.,汪冰.,王萌.,...&Chai, ZF.(2009).Particokinetics and Extrapulmonary Translocation of Intratracheally Instilled Ferric Oxide Nanoparticles in Rats and the Potential Health Risk Assessment.TOXICOLOGICAL SCIENCES,107(2),342-351.
MLA 朱墨桃,et al."Particokinetics and Extrapulmonary Translocation of Intratracheally Instilled Ferric Oxide Nanoparticles in Rats and the Potential Health Risk Assessment".TOXICOLOGICAL SCIENCES 107.2(2009):342-351.
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