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Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis
Wang HJ(王华建); Wang M(王萌); Wang B(汪冰); Wang Y(王云); Li M(李明); Feng WY(丰伟悦); Zhao YL(赵宇亮); Chai ZF(柴之芳); Wang, HJ; Wang, M; Wang, B; Meng, XY; Wang, Y; Li, M; Feng, WY; Zhao, YL; Chai, ZF
刊名JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
2010
卷号25期号:3页码:328-333
学科分类Chemistry; Spectroscopy
DOI10.1039/b921201a
通讯作者[Wang, Hua-Jian ; Wang, Meng ; Wang, Bing ; Wang, Yun ; Li, Ming ; Feng, Wei-Yue ; Zhao, Yu-Liang ; Chai, Zhi-Fang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Wang, Hua-Jian ; Wang, Meng ; Wang, Bing ; Wang, Yun ; Li, Ming ; Feng, Wei-Yue ; Zhao, Yu-Liang ; Chai, Zhi-Fang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Wang, Hua-Jian ; Wang, Yun ; Li, Ming] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China ; [Meng, Xiang-Yu] Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Jilin, Peoples R China
文章类型Article
英文摘要A method for quantitative imaging of trace elements in sections of bio-tissues using synchrotron radiation microbeam X-ray fluorescence (SR-mu XRF) analysis was developed. The Compton scattering in the SR-mu XRF spectrum was utilized as an internal standard to compensate the differences in thickness and density of thin bio-tissue sections. The ratios of element sensitivities to Compton scattering peak obtained from two matrix-matched standard reference materials were used for the calculation of the concentrations of metals in a brain section. The concentrations of Ca, Fe, Cu and Zn in the standard reference material (GBW 08551, pig liver) determined by this method were in good agreement with the certified values. The detection limits of Ca, Fe, Cu and Zn at 2 s detection were 1.15, 0.53, 0.21, and 0.20 mu g g(-1), respectively. The method has been successfully applied in accurate and precise imaging of the element variations in the brain section of a transgenic mouse model of Alzheimer's disease.
类目[WOS]Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
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语种英语
WOS记录号WOS:000274961600009
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被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/237001
专题院士_期刊论文
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_粒子天体物理中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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Wang HJ,Wang M,Wang B,et al. Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis[J]. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,2010,25(3):328-333.
APA 王华建.,王萌.,汪冰.,王云.,李明.,...&Chai, ZF.(2010).Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis.JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,25(3),328-333.
MLA 王华建,et al."Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis".JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 25.3(2010):328-333.
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