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Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure
Wang Y(王云); Wang B(汪冰); Zhu MT(朱墨桃); Li M(李明); Wang HJ(王华建); Wang M(王萌); Ou YH(欧阳宏); Chai ZF(柴之芳); Feng WY(丰伟悦); Zhao YL(赵宇亮); Wang, Y; Wang, B; Zhu, MT; Li, M; Wang, HJ; Wang, M; Ouyang, H; Chai, ZF; Feng, WY; Zhao, YL
刊名TOXICOLOGY LETTERS
2011
卷号205期号:1页码:26-37
关键词Ferric oxide nanoparticles Neurotoxicity Microglial activation
学科分类Toxicology
DOI10.1016/j.toxlet.2011.05.001
通讯作者[Wang, Yun ; Wang, Bing ; Zhu, Mo-Tao ; Li, Ming ; Wang, Hua-Jian ; Wang, Meng ; Ouyang, Hong ; Chai, Zhi-Fang ; Feng, Wei-Yue ; Zhao, Yu-Liang] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Wang, Yun ; Wang, Bing ; Zhu, Mo-Tao ; Li, Ming ; Wang, Hua-Jian ; Wang, Meng ; Ouyang, Hong ; Chai, Zhi-Fang ; Feng, Wei-Yue ; Zhao, Yu-Liang] Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Wang, Yun] Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
文章类型Article
英文摘要Microglia as the resident macrophage-like cells in the central nervous system (CNS) play a pivotal role in the innate immune responses of CNS. Understanding the reactions of microglia cells to nanoparticle exposure is important in the exploration of neurobiology of nanoparticles. Here we provide a systemic mapping of microglia and the corresponding pathological changes in olfactory-transport related brain areas of mice with Fe(2)O(3)-nanoparticle intranasal treatment. We showed that intranasal exposure of Fe(2)O(3) nanoparticle could lead to pathological alteration in olfactory bulb, hippocampus and striatum, and caused microglial proliferation, activation and recruitment in these areas, especially in olfactory bulb. Further experiments with BV2 microglial cells showed the exposure to Fe(2)O(3) nanoparticles could induce cells proliferation, phagocytosis and generation of ROS and NO, but did not cause significant release of inflammatory factors, including IL-1 beta, IL-6 and TNF-alpha. Our results indicate that microglial activation may act as an alarm and defense system in the processes of the exogenous nanoparticles invading and storage in brain. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
类目[WOS]Toxicology
研究领域[WOS]Toxicology
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语种英语
WOS记录号WOS:000293321200004
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被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/236794
专题院士_期刊论文
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_粒子天体物理中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Wang Y,Wang B,Zhu MT,et al. Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure[J]. TOXICOLOGY LETTERS,2011,205(1):26-37.
APA 王云.,汪冰.,朱墨桃.,李明.,王华建.,...&Zhao, YL.(2011).Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure.TOXICOLOGY LETTERS,205(1),26-37.
MLA 王云,et al."Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure".TOXICOLOGY LETTERS 205.1(2011):26-37.
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