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Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release
Huang; S; Liu; J; He; Q; Chen; HL; Cui; JB; Xu; SY; Zhao; YL; Chen; CY; Wang; LY; Zhao YL(赵宇亮)
2015
Source PublicationNANO RESEARCH
ISSN1998-0124
EISSN1998-0000
Volume8Issue:12Pages:4038-4047
SubtypeArticle
AbstractThermosensitive drug delivery systems (DDSs) face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near-infrared (NIR) photothermal Cu1.75S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine (DOX) loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions (pH = 7.4, 37 A degrees C) for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous longterm NIR irradiation. Based on the stable and high photothermal efficiency (55.8%), pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstrating remote and noninvasive control.
Keywordcopper sulfides near infrared light photothermal therapy drug release
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1007/s12274-015-0905-9
Indexed BySCI
Language英语
WOS Research AreaChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS IDWOS:000367003400028
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/229070
Collection多学科研究中心
Recommended Citation
GB/T 7714
Huang,S,Liu,et al. Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release[J]. NANO RESEARCH,2015,8(12):4038-4047.
APA Huang.,S.,Liu.,J.,He.,...&赵宇亮.(2015).Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release.NANO RESEARCH,8(12),4038-4047.
MLA Huang,et al."Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release".NANO RESEARCH 8.12(2015):4038-4047.
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