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Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release
Huang; S; Liu; J; He; Q; Chen; HL; Cui; JB; Xu; SY; Zhao; YL; Chen; CY; Wang; LY; Zhao YL(赵宇亮)
2015
发表期刊NANO RESEARCH
卷号8期号:12页码:4038-4047
摘要Thermosensitive drug delivery systems (DDSs) face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near-infrared (NIR) photothermal Cu1.75S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine (DOX) loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions (pH = 7.4, 37 A degrees C) for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous longterm NIR irradiation. Based on the stable and high photothermal efficiency (55.8%), pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstrating remote and noninvasive control.
文章类型Article
关键词copper sulfides near infrared light photothermal therapy drug release
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1007/s12274-015-0905-9
收录类别SCI
WOS类目Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000367003400028
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/229070
专题多学科研究中心
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Huang,S,Liu,et al. Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release[J]. NANO RESEARCH,2015,8(12):4038-4047.
APA Huang.,S.,Liu.,J.,He.,...&赵宇亮.(2015).Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release.NANO RESEARCH,8(12),4038-4047.
MLA Huang,et al."Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release".NANO RESEARCH 8.12(2015):4038-4047.
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