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Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging
Wang; GH; Wang; JJ; Zhan; J; Nie; BB; Li; PL; Fan; LD; Zhu; HT; Feng; T; Shan; BC; Wang JJ(王静娟); Nie BB(聂彬彬); Zhu HT(朱海涛); Dan BC(单保慈)
2015
发表期刊JOURNAL OF THE NEUROLOGICAL SCIENCES
卷号359期号:1-2页码:367-372
通讯作者单保慈
文章类型Article
摘要Purpose: To investigate the gray matter (GM) atrophy in Progressive supranuclear palsy (PSP) using T1-weighted Fluid-Attenuated Inversion Recovery (FLAIR) images based on voxel based morphometry (VBM) method. Materials and methods: In this study, we firstly modified the conventional VBM method to make it can process the T1-weighted HAIR brain images. Then, we used this method on the 24 PSP patients and 23 healthy age- and sex-matched control subjects to find the local gray matter density changes of PSP patients. Results: Compared with healthy controls, GM reductions of PSP patients mainly located in the thalamus, basal ganglia, pons, midbrain, insular cortex, frontal cortex, temporal lobe, cerebellum, cingulate cortex and hippocampus. Conclusion: We used the modified VBM technique into T1 FLAIR data to study the brain gray matter atrophy in PSP, and found some new atrophy areas, including pallidum, middle and posterior cingulum, lingual, fusiform gyrus and the post part of inferior temporal gyrus. These areas have not been described in the former VBM studies, but they revealed abnormity in the pathologic and other studies on PSP. Our results might be expected to provide significant underlining neurology information and diagnostic value for PSP. (C) 2015 Elsevier B.V. All tights reserved.
关键词PSP VBM Gray matter atrophy MRI T1-weighted FLAIR imaging Quantitative assessment
学科领域Neurosciences & Neurology
DOI10.1016/j.jns.2015.11.007
收录类别SCI
WOS类目Clinical Neurology ; Neurosciences
WOS记录号WOS:000367276200069
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/229066
专题核技术应用研究中心
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Wang,GH,Wang,et al. Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES,2015,359(1-2):367-372.
APA Wang.,GH.,Wang.,JJ.,Zhan.,...&单保慈.(2015).Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging.JOURNAL OF THE NEUROLOGICAL SCIENCES,359(1-2),367-372.
MLA Wang,et al."Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging".JOURNAL OF THE NEUROLOGICAL SCIENCES 359.1-2(2015):367-372.
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