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Computational studies on the interactions of nanomaterials with proteins and their impacts
An DY(安德义); An; DY; Su; JG; Li; CH; Li; JY; Li JY(李敬源)
2015
发表期刊CHINESE PHYSICS B
卷号24期号:12页码:120504
通讯作者李敬源
摘要The intensive concern over the biosafety of nanomaterials demands the systematic study of the mechanisms underlying their biological effects. Many of the effects of nanomaterials can be attributed to their interactions with proteins and their impacts on protein function. On the other hand, nanomaterials show potential for a variety of biomedical applications, many of which also involve direct interactions with proteins. In this paper, we review some recent computational studies on this subject, especially those investigating the interactions of carbon and gold nanomaterials. Beside hydrophobic and pi-stacking interactions, the mode of interaction of carbon nanomaterials can also be regulated by their functional groups. The coatings of gold nanomaterials similarly adjust their mode of interaction, in addition to coordination interactions with the sulfur groups of cysteine residues and the imidazole groups of histidine residues. Nanomaterials can interact with multiple proteins and their impacts on protein activity are attributed to a wide spectrum of mechanisms. These findings on the mechanisms of nanomaterial-protein interactions can further guide the design and development of nanomaterials to realize their application in disease diagnosis and treatment.
文章类型Review
关键词molecular dynamics simulation biological effect nanomaterial protein
学科领域Physics
DOI10.1088/1674-1056/24/12/120504
收录类别SCI ; EI
WOS类目Physics, Multidisciplinary
WOS记录号WOS:000366977800014
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/229056
专题多学科研究中心
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GB/T 7714
An DY,An,DY,et al. Computational studies on the interactions of nanomaterials with proteins and their impacts[J]. CHINESE PHYSICS B,2015,24(12):120504.
APA 安德义.,An.,DY.,Su.,JG.,...&李敬源.(2015).Computational studies on the interactions of nanomaterials with proteins and their impacts.CHINESE PHYSICS B,24(12),120504.
MLA 安德义,et al."Computational studies on the interactions of nanomaterials with proteins and their impacts".CHINESE PHYSICS B 24.12(2015):120504.
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