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Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine
Xu; M.; Xing XQ(邢雪青); Wu ZH(吴忠华); X. Xing; Z. Wu; Y. Du; T. Hu
2015
Source PublicationVaccine
ISSN0264-410X
EISSN1873-2518
Volume33Issue:43Pages:5815-5821
SubtypeArticle
AbstractNeisseria meningitidis is a leading cause of severe bacterial infections in infants and young children. As a major virulence factor, meningococcal capsular polysaccharide (PS) is poorly immunogenic and generally does not induce immunological memory. Conjugation of PS with a carrier protein can significantly increase the PS-specific immunogenicity and induce immunological memory. It is well known that the molecular shape/size of the conjugate vaccine is important for its immunogenicity. However, little is known about the molecular shape/size of the meningococcal conjugate vaccine. A meningococcal PS ovalbumin (OVA) conjugate vaccine was prepared using cystamine as linker. Four components (P1-P4) with different molecular size were fractionated from the conjugate. Small angle X-ray scattering (SAXS) analysis revealed that the conjugate vaccine exhibited a rod-like shape similar to virus-like particles. PS-specific immunogenicity of the conjugate vaccine was related to its molecular shape and increased as a function of its molecular size. Thus, the present study provides a three-dimensional shape of the conjugate vaccine and helps to identify optimal design of a potent meningococcal conjugate vaccine. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordNeisseria meningitidis Polysaccharide Conjugate vaccine SAXS Molecular shape
Subject AreaImmunology; Research & Experimental Medicine
DOI10.1016/j.vaccine.2015.09.021
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Medicine, Research & Experimental
WOS SubjectImmunology ; Research & Experimental Medicine
WOS IDWOS:000363824600013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228958
Collection多学科研究中心
Recommended Citation
GB/T 7714
Xu,M.,Xing XQ,et al. Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine[J]. Vaccine,2015,33(43):5815-5821.
APA Xu.,M..,邢雪青.,吴忠华.,X. Xing.,...&T. Hu.(2015).Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine.Vaccine,33(43),5815-5821.
MLA Xu,et al."Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine".Vaccine 33.43(2015):5815-5821.
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