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Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy
Yong Y(雍媛); Bo T(薄涛); Zu M(祖勉); Yan L(晏亮); Yin WY(尹文艳); Wang DL(王栋梁); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yong; Y; Cheng; XJ; Bao; T; Zu; M; Yan; L; Yin; WY; Ge; CC; Wang; DL; Gu; ZJ; Zhao; YL
2015
Source PublicationACS NANO
ISSN1936-0851
EISSN1936-086X
Volume9Issue:12Pages:12451-12463
Corresponding Author谷战军 ; 赵宇亮
SubtypeArticle
AbstractDesigning a multifunctional nanomedicine for integration of precise diagnosis and effective treatment of tumors is desirable but remains a great challenge. Here, we report a multifunctional nanomedicine based on WS2 quantum dots (QDs), which was prepared by a facile and "green" method through physical grinding and ultrasonication. The as-obtained WS2 QDs with small size (3 nm) possess not only significant X-ray computed tomography (CT)/photoaccoustic (PA) imaging signal enhancement but also remarkable photothermal therapy (PTT)/radiotherapy (RT) synergistic effect for tumor treatment. With CT/PA imaging and the synergistic effect between PTT and RT, the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of WS2 QDs. Moreover, hematoxylin and eosin staining, blood hematology, and biochemistry analysis revealed no noticeable toxicity of WS2 QDs in vitro and in vivo, which confirmed that WS2 QDs possess good biocompatibility. This multifunctional nanoparticle could play an important role in facilitating simultaneously multimodal imaging and synergistic therapy between PTT and RI to achieve better therapeutic efficacy.
KeywordWS2 quantum dots X-ray computed tomography photoaccoustic imaging photothermal therapy radiotherapy therapy synergistic therapy
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science
DOI10.1021/acsnano.5b05825
Indexed BySCI ; EI ; CA
Language英语
WOS Research AreaChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science
WOS IDWOS:000367280100098
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228881
Collection多学科研究中心
Recommended Citation
GB/T 7714
Yong Y,Bo T,Zu M,et al. Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy[J]. ACS NANO,2015,9(12):12451-12463.
APA 雍媛.,薄涛.,祖勉.,晏亮.,尹文艳.,...&YL.(2015).Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy.ACS NANO,9(12),12451-12463.
MLA 雍媛,et al."Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy".ACS NANO 9.12(2015):12451-12463.
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