IHEP OpenIR  > 多学科研究中心
Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy
Yong Y(雍媛); Bo T(薄涛); Zu M(祖勉); Yan L(晏亮); Yin WY(尹文艳); Wang DL(王栋梁); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yong; Y; Cheng; XJ; Bao; T; Zu; M; Yan; L; Yin; WY; Ge; CC; Wang; DL; Gu; ZJ; Zhao; YL
2015
发表期刊ACS NANO
卷号9期号:12页码:12451-12463
通讯作者谷战军 ; 赵宇亮
摘要Designing a multifunctional nanomedicine for integration of precise diagnosis and effective treatment of tumors is desirable but remains a great challenge. Here, we report a multifunctional nanomedicine based on WS2 quantum dots (QDs), which was prepared by a facile and "green" method through physical grinding and ultrasonication. The as-obtained WS2 QDs with small size (3 nm) possess not only significant X-ray computed tomography (CT)/photoaccoustic (PA) imaging signal enhancement but also remarkable photothermal therapy (PTT)/radiotherapy (RT) synergistic effect for tumor treatment. With CT/PA imaging and the synergistic effect between PTT and RT, the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of WS2 QDs. Moreover, hematoxylin and eosin staining, blood hematology, and biochemistry analysis revealed no noticeable toxicity of WS2 QDs in vitro and in vivo, which confirmed that WS2 QDs possess good biocompatibility. This multifunctional nanoparticle could play an important role in facilitating simultaneously multimodal imaging and synergistic therapy between PTT and RI to achieve better therapeutic efficacy.
文章类型Article
关键词WS2 quantum dots X-ray computed tomography photoaccoustic imaging photothermal therapy radiotherapy therapy synergistic therapy
学科领域Chemistry; Science & Technology - Other Topics; Materials Science
DOI10.1021/acsnano.5b05825
收录类别SCI ; EI ; CA
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000367280100098
引用统计
被引频次:103[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228881
专题多学科研究中心
推荐引用方式
GB/T 7714
Yong Y,Bo T,Zu M,et al. Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy[J]. ACS NANO,2015,9(12):12451-12463.
APA 雍媛.,薄涛.,祖勉.,晏亮.,尹文艳.,...&YL.(2015).Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy.ACS NANO,9(12),12451-12463.
MLA 雍媛,et al."Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy".ACS NANO 9.12(2015):12451-12463.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2017.pdf(2383KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[雍媛]的文章
[薄涛]的文章
[祖勉]的文章
百度学术
百度学术中相似的文章
[雍媛]的文章
[薄涛]的文章
[祖勉]的文章
必应学术
必应学术中相似的文章
[雍媛]的文章
[薄涛]的文章
[祖勉]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 2017.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。