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| Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand | |
Lu HR(卢会茹); Chen J(陈俊) ; Liu XX(刘潇潇); Wu HC(吴海臣); Zhao YL(赵宇亮); Chai ZF(柴之芳); Hu Y(胡毅); Lu; H.; S. Li; J. Chen; J. Xia; J. Zhang; Y. Huang; X. Liu; H.-c. Wu; Y. Zhao; Z. Chai; Y. Hu
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| 2015 | |
| Source Publication | Metallomics
 |
| ISSN | 1756-5901 |
| EISSN | 1756-591X |
| Volume | 7Issue:11Pages:1508-1514 |
| Corresponding Author | 胡毅 |
| Subtype | Article |
| Abstract | Small-molecule ligands for stabilizing the G-quadruplex in telomeres are promising chemotherapeutic agents. Despite extensive research, few G-quadruplex-stabilizing ligands have been clinically approved to date. We hypothesized that metal ions may be able to interfere with the ligand-mediated stabilization of the G-quadruplex. Here we found that several metal ions could interfere with the Na+-induced G-quadruplex conformation even in the presence of a ligand. The destabilizing effects of metal ions may not be negligible as most of them are essential elements in organisms. In contrast, Ba2+ was found to be a potent stabilizing cation, which could compete with other destabilizing cations to modulate the stability of the G-quadruplex. Moreover, the destabilizing effects of divalent or trivalent cations were considerably inhibited when a metal chelator was used. These data suggested that the unfavorable effects of destabilizing cations must be minimized for enhancing the ligand-mediated stabilization of the G-quadruplex. |
| Subject Area | Biochemistry & Molecular Biology |
| DOI | 10.1039/c5mt00188a |
| Indexed By | SCI ; EI ; CA ; MEDLINE |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology |
| WOS Subject | Biochemistry & Molecular Biology |
| WOS ID | WOS:000364822500005 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/228874 |
| Collection | 院士 多学科研究中心 |
| Recommended Citation GB/T 7714 | Lu HR,Chen J,Liu XX,et al. Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand[J]. Metallomics,2015,7(11):1508-1514. |
| APA | 卢会茹.,陈俊.,刘潇潇.,吴海臣.,赵宇亮.,...&Y. Hu.(2015).Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand.Metallomics,7(11),1508-1514. |
| MLA | 卢会茹,et al."Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand".Metallomics 7.11(2015):1508-1514. |
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