IHEP OpenIR  > 院士
Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand
Lu HR(卢会茹); Chen J(陈俊); Liu XX(刘潇潇); Wu HC(吴海臣); Zhao YL(赵宇亮); Chai ZF(柴之芳); Hu Y(胡毅); Lu; H.; S. Li; J. Chen; J. Xia; J. Zhang; Y. Huang; X. Liu; H.-c. Wu; Y. Zhao; Z. Chai; Y. Hu
2015
发表期刊Metallomics
卷号7期号:11页码:1508-1514
通讯作者胡毅
摘要Small-molecule ligands for stabilizing the G-quadruplex in telomeres are promising chemotherapeutic agents. Despite extensive research, few G-quadruplex-stabilizing ligands have been clinically approved to date. We hypothesized that metal ions may be able to interfere with the ligand-mediated stabilization of the G-quadruplex. Here we found that several metal ions could interfere with the Na+-induced G-quadruplex conformation even in the presence of a ligand. The destabilizing effects of metal ions may not be negligible as most of them are essential elements in organisms. In contrast, Ba2+ was found to be a potent stabilizing cation, which could compete with other destabilizing cations to modulate the stability of the G-quadruplex. Moreover, the destabilizing effects of divalent or trivalent cations were considerably inhibited when a metal chelator was used. These data suggested that the unfavorable effects of destabilizing cations must be minimized for enhancing the ligand-mediated stabilization of the G-quadruplex.
文章类型Article
学科领域Biochemistry & Molecular Biology
DOI10.1039/c5mt00188a
收录类别SCI ; EI ; CA ; MEDLINE
WOS类目Biochemistry & Molecular Biology
WOS记录号WOS:000364822500005
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228874
专题院士
多学科研究中心
推荐引用方式
GB/T 7714
Lu HR,Chen J,Liu XX,et al. Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand[J]. Metallomics,2015,7(11):1508-1514.
APA 卢会茹.,陈俊.,刘潇潇.,吴海臣.,赵宇亮.,...&Y. Hu.(2015).Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand.Metallomics,7(11),1508-1514.
MLA 卢会茹,et al."Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand".Metallomics 7.11(2015):1508-1514.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2010.pdf(2483KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[卢会茹]的文章
[陈俊]的文章
[刘潇潇]的文章
百度学术
百度学术中相似的文章
[卢会茹]的文章
[陈俊]的文章
[刘潇潇]的文章
必应学术
必应学术中相似的文章
[卢会茹]的文章
[陈俊]的文章
[刘潇潇]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 2010.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。