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99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent
Wang JJ(汪建军); Zhang YH(张延华); Yang WJ(杨文江); Xue JQ(薛井泉); 刘宇(多); Wang, J.; Zhang, Y.; Yang, W.; Xue, J.; Liu, Y.
2016
发表期刊JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
卷号307期号:2页码:1087-1092
通讯作者汪建军 ; 刘宇(多)
摘要For the purpose to develop novel 99mTc-labeled tumor imaging agents with SPECT, colchicine (CHC) was directly labeled by 99mTc using diethylene triamine pentacetate acid (DTPA) as bifunctional chelating agent. Trimethylcolchicinic acid, derivatived from colchicine, was conjugated to DTPA to get the new ligand DTPA-CHC, which was labeled by 99mTc in the presence of SnCl2 as reducing agent. The radiochem. purity of the 99mTc-DTPA-CHC complex was over 90 %. It had good hydrophilicity and was stable at room temp. The high initial tumor uptake with moderate retention, good tumor/muscle ratios and satisfactory scintigraphic images highlighted the potential of 99mTc-DTPA-CHC for tumor imaging. [on SciFinder(R)]
文章类型Article
DOI10.1007/s10967-015-4308-x
收录类别CA
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228868
专题多学科研究中心
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Wang JJ,Zhang YH,Yang WJ,et al. 99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2016,307(2):1087-1092.
APA 汪建军.,张延华.,杨文江.,薛井泉.,刘宇.,...&Liu, Y..(2016).99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,307(2),1087-1092.
MLA 汪建军,et al."99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 307.2(2016):1087-1092.
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