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Recent Advances in Upconversion Nanoparticles-Based Multifunctional Nanocomposites for Combined Cancer Therapy
Tian G(田甘); Zhang X(张潇); Gu ZJ(谷战军); Zhao YL(赵宇亮); Tian, G; Zhang, X; Gu, ZJ; Zhao, YL
2015
Source PublicationADVANCED MATERIALS
ISSN0935-9648
EISSN1521-4095
Volume27Issue:47Pages:7692-7712
Corresponding Author谷战军 ; 赵宇亮
SubtypeReview
AbstractLanthanide-doped upconversion nanoparticles (UCNPs) have the ability to generate ultraviolet or visible emissions under continuous-wave near-infrared (NIR) excitation. Utilizing this special luminescence property, UCNPs are approved as a new generation of contrast agents in optical imaging with deep tissue-penetration ability and high signal-to-noise ratio. The integration of UCNPs with other functional moieties can endow them with highly enriched functionalities for imaging-guided cancer therapy, which makes composites based on UCNPs emerge as a new class of theranostic agents in biomedicine. Here, recent progress in combined cancer therapy using functional nanocomposites based on UCNPs is reviewed. Combined therapy referring to the co-delivery of two or more therapeutic agents or a combination of different treatments is becoming more popular in clinical treatment of cancer because it generates synergistic anti-cancer effects, reduces individual drug-related toxicity and suppresses multi-drug resistance through different mechanisms of action. Here, the recent advances of combined therapy contributed by UCNPs-based nanocomposites on two main branches are reviewed: i) photodynamic therapy and ii) chemotherapy, which are the two most widely adopted therapies of UCNPs-based composites. The future prospects and challenges in this emerging field will be also discussed.
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/adma.201503280
Indexed BySCI ; EI ; CA
Language英语
WOS Research AreaChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS IDWOS:000367837900001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228867
Collection中国科学院高能物理研究所
Recommended Citation
GB/T 7714
Tian G,Zhang X,Gu ZJ,et al. Recent Advances in Upconversion Nanoparticles-Based Multifunctional Nanocomposites for Combined Cancer Therapy[J]. ADVANCED MATERIALS,2015,27(47):7692-7712.
APA 田甘.,张潇.,谷战军.,赵宇亮.,Tian, G.,...&Zhao, YL.(2015).Recent Advances in Upconversion Nanoparticles-Based Multifunctional Nanocomposites for Combined Cancer Therapy.ADVANCED MATERIALS,27(47),7692-7712.
MLA 田甘,et al."Recent Advances in Upconversion Nanoparticles-Based Multifunctional Nanocomposites for Combined Cancer Therapy".ADVANCED MATERIALS 27.47(2015):7692-7712.
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