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Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer
Zhong, XY; Yang, K; Dong, ZL; Yi, X; Wang, Y; Ge, CC; Zhao, YL; Liu, Z; Zhao YL(赵宇亮)
2015
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
EISSN1616-3028
Volume25Issue:47Pages:7327-7336
SubtypeArticle
AbstractDevelopment of biodegradable nanomaterials for drug delivery and cancer theranostics has attracted great attention in recent years. In this work, polydopamine (PDA), a biocompatible polymer, is developed as a promising carrier for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy (RIT) and chemotherapy of cancer in one system. It is found that PDA nanoparticles after modification with poly(ethylene glycol) (PEG) can successfully load several different radionuclides such as Tc-99m and I-131, as well as an anticancer drug doxorubicin (DOX). While labeling PDA-PEG with Tc-99m (Tc-99m-PDA-PEG) enables in vivo single photon emission computed tomography imaging, nanoparticles co-loaded with I-131 and DOX (I-131-PDA-PEG/DOX) can be utilized for combined RIT and chemotherapy, which offers effective cancer treatment efficacy in a remarkably synergistic manner, without rendering significant toxicity to the treated animals. Therefore, this study presents an interesting class of biocompatible nanocarriers, which allow the combination of RIT and chemotherapy, the two extensively applied cancer therapeutic strategies, promising for future clinic translations in cancer treatment.
Keyworddrug delivery polydopamine radioisotope therapy radiolabeling SPECT imaging
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/adfm.201503587
Indexed BySCI ; EI
Language英语
WOS Research AreaChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS IDWOS:000366504100009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228853
Collection多学科研究中心
Recommended Citation
GB/T 7714
Zhong, XY,Yang, K,Dong, ZL,et al. Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(47):7327-7336.
APA Zhong, XY.,Yang, K.,Dong, ZL.,Yi, X.,Wang, Y.,...&赵宇亮.(2015).Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer.ADVANCED FUNCTIONAL MATERIALS,25(47),7327-7336.
MLA Zhong, XY,et al."Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer".ADVANCED FUNCTIONAL MATERIALS 25.47(2015):7327-7336.
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