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Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer
Zhong, XY; Yang, K; Dong, ZL; Yi, X; Wang, Y; Ge, CC; Zhao, YL; Liu, Z; Zhao YL(赵宇亮)
2015
发表期刊ADVANCED FUNCTIONAL MATERIALS
卷号25期号:47页码:7327-7336
摘要Development of biodegradable nanomaterials for drug delivery and cancer theranostics has attracted great attention in recent years. In this work, polydopamine (PDA), a biocompatible polymer, is developed as a promising carrier for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy (RIT) and chemotherapy of cancer in one system. It is found that PDA nanoparticles after modification with poly(ethylene glycol) (PEG) can successfully load several different radionuclides such as Tc-99m and I-131, as well as an anticancer drug doxorubicin (DOX). While labeling PDA-PEG with Tc-99m (Tc-99m-PDA-PEG) enables in vivo single photon emission computed tomography imaging, nanoparticles co-loaded with I-131 and DOX (I-131-PDA-PEG/DOX) can be utilized for combined RIT and chemotherapy, which offers effective cancer treatment efficacy in a remarkably synergistic manner, without rendering significant toxicity to the treated animals. Therefore, this study presents an interesting class of biocompatible nanocarriers, which allow the combination of RIT and chemotherapy, the two extensively applied cancer therapeutic strategies, promising for future clinic translations in cancer treatment.
文章类型Article
关键词drug delivery polydopamine radioisotope therapy radiolabeling SPECT imaging
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/adfm.201503587
收录类别SCI ; EI
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000366504100009
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被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228853
专题多学科研究中心
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GB/T 7714
Zhong, XY,Yang, K,Dong, ZL,et al. Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(47):7327-7336.
APA Zhong, XY.,Yang, K.,Dong, ZL.,Yi, X.,Wang, Y.,...&赵宇亮.(2015).Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer.ADVANCED FUNCTIONAL MATERIALS,25(47),7327-7336.
MLA Zhong, XY,et al."Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer".ADVANCED FUNCTIONAL MATERIALS 25.47(2015):7327-7336.
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