Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China
Li, J; Wang, YF; Kong, DD; Wang, JS; Teng, YG; Li, N; 李娜(多)
刊名ENVIRONMENTAL MONITORING AND ASSESSMENT
2015
卷号187期号:11页码:724
关键词In vitro bioassay Estrogen receptor Androgen receptor Soil sample Endocrine-disrupting chemicals
学科分类Environmental Sciences & Ecology
DOI10.1007/s10661-015-4933-4
文章类型Article
英文摘要In the present study, re-combined estrogen receptor (ER) and androgen receptor (AR) gene yeast assays combined with a novel approach based on Monte Carlo simulation were used for evaluation and characterization of soil samples collected from Jilin along the Second Songhua River to assess their antagonist/agonist properties for ER and AR. The results showed that estrogenic activity only occurred in the soil samples collected in the agriculture area, but most soil samples showed anti-estrogenic activities, and the bioassay-derived 4-hydroxytamoxifen equivalents ranged from N.D. to 23.51 mu g/g. Hydrophilic substance fractions were determined as potential contributors associated with anti-estrogenic activity in these soil samples. Moreover, none of the soil samples exhibited AR agonistic potency, whereas 54 % of the soil samples exhibited AR antagonistic potency. The flutamide equivalents varied between N.D. and 178.05 mu g/g. Based on Monte Carlo simulation-related mass balance analysis, the AR antagonistic activities were significantly correlated with the media polar and polar fractions. All of these results support that this novel calculation method can be adopted effectively to quantify and characterize the ER/AR agonists and antagonists of the soil samples, and these data could help provide useful information for future management and remediation efforts.
类目[WOS]Environmental Sciences
收录类别SCI ; EI
WOS记录号WOS:000363964000066
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228830
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
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Li, J,Wang, YF,Kong, DD,et al. Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China[J]. ENVIRONMENTAL MONITORING AND ASSESSMENT,2015,187(11):724.
APA Li, J.,Wang, YF.,Kong, DD.,Wang, JS.,Teng, YG.,...&李娜.(2015).Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China.ENVIRONMENTAL MONITORING AND ASSESSMENT,187(11),724.
MLA Li, J,et al."Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China".ENVIRONMENTAL MONITORING AND ASSESSMENT 187.11(2015):724.
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