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Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging
Cao, MJ; Wang, PY; Kou, Y; Wang, J; Liu, J; Li, YH; Li, JY; Wang, LM; Chen, CY; Wang LM(王黎明)
2015
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号7期号:45页码:25014-25023
文章类型Article
摘要The combination of therapy and diagnosis has been emerging as a promising strategy for cancer treatment. To realize chemotherapy, photothermal therapy, and magnetic resonance imaging (MRI) in one system, we have synthesized a new magnetic nanoparticle (Gd@SiO2-DOX/ICG-PDC) integrating doxorubicin (DOX), indocyanine green (ICG), and gadolinium(III)-chelated silica nanospheres (Gd@SiO2) with a poly(diallyldimethylammonium chloride) (PDC) coating. PDC coating serves as a polymer layer to protect from quick release of drugs from the nanocarriers and increase cellular uptake. The DOX release from Gd@SiO2-DOX/ICG-PDC depends on pH and temperature. The process will be accelerated in the acidic condition than in a neutral pH 7.4. Meanwhile, upon laser irradiation, the photothermal effects promote DOX release and improve the therapeutic efficacy compared to either DOX-loaded Gd@SiO2 or ICG-loaded Gd@SiO2. Moreover, MRI results show that the Gd@SiO2-PDC nanoparticles are safe T-1-type MRI contrast agents for imaging. The Gd@SiO2-PDC nanoparticles loaded with DOX and ICG can thus act as a promising theranostic platform for multimodal cancer treatment.
关键词photothermal therapy magnetic resonance imaging chemotherapy multimodal therapy drug delivery mesoporous silica nanoparticles gadolinium(III)-chelated silica nanospheres
学科领域Science & Technology - Other Topics; Materials Science
DOI10.1021/acsami.5b06938
收录类别SCI ; EI ; CA
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000365148600007
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228806
专题多学科研究中心
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Cao, MJ,Wang, PY,Kou, Y,et al. Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(45):25014-25023.
APA Cao, MJ.,Wang, PY.,Kou, Y.,Wang, J.,Liu, J.,...&王黎明.(2015).Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,7(45),25014-25023.
MLA Cao, MJ,et al."Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 7.45(2015):25014-25023.
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