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Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner
Cheng, XJ; Tian, X; Wu, AQ; Li, JX; Tian, J; Chong, Y; Chai, ZF; Zhao, YL; Chen, CY; Ge, CC; Chai ZF(柴之芳)
2015
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号7期号:37页码:20568-20575
文章类型Article
摘要The interaction at nanobio is a critical issue in designing safe nanomaterials for biomedical applications. Recent studies have reported that it is nanoparticle-protein corona rather than bare nanoparticle that determines the nanoparticle cell interactions, including endocytic pathway and biological responses. Here, we demonstrate the effects of protein corona on cellular uptake of different sized gold nanoparticles in different cell lines. The experimental results show that protein corona significantly decreases the internalization of Au NPs in a particle size- and cell type-dependent manner. Protein corona exhibits much more significant inhibition on the uptake of large-sized Au NPs by phagocytic cell than that of small-sized Au NPs by nonphagocytic cell. The endocytosis experiment indicates that different endocytic pathways might be responsible for the differential roles of protein corona in the interaction of different sized Au NPs with different cell lines. Our findings can provide useful information for rational design of nanomaterials in biomedical application.
关键词gold nanoparticle size protein corona cell line uptake level endocytic pathways
学科领域Science & Technology - Other Topics; Materials Science
DOI10.1021/acsami.5b04290
收录类别SCI ; EI
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000361931600010
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228784
专题院士
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GB/T 7714
Cheng, XJ,Tian, X,Wu, AQ,et al. Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(37):20568-20575.
APA Cheng, XJ.,Tian, X.,Wu, AQ.,Li, JX.,Tian, J.,...&柴之芳.(2015).Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner.ACS APPLIED MATERIALS & INTERFACES,7(37),20568-20575.
MLA Cheng, XJ,et al."Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner".ACS APPLIED MATERIALS & INTERFACES 7.37(2015):20568-20575.
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