Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer
Khalid, A; Wolfram, J; Ferrari, I; Mu, CF; Mai, JH; Yang, ZZ; Zhao, YL; Ferrari, M; Ma, XJ; Shen, HF; Zhao YL(赵宇亮)
刊名MINI-REVIEWS IN MEDICINAL CHEMISTRY
2015
卷号15期号:13页码:1063-1072
关键词Breast cancer CCL5 CCR5 mesenchymal stem cells metastasis triple-negative breast cancer
学科分类Pharmacology & Pharmacy
DOI10.2174/138955751513150923094709
文章类型Review
英文摘要A variety of therapeutic strategies are currently under investigation to inhibit factors that promote tumor invasion, as metastasis is the most common cause of mortality for cancer patients. Notably, considerable emphasis has been placed on studying metastasis as a dynamic process that is highly dependent on the tumor microenvironment. In regards to breast cancer, chemokine C-C motif ligand 5 (CCL5), which is produced by tumor-associated stromal cells, has been established as an important contributor to metastatic disease. This review summarizes recent discoveries uncovering the role of this chemokine in breast cancer metastasis, including conditions that increase the generation of CCL5 and effects induced by this signaling pathway. In particular, CCL-5-mediated cancer cell migration and invasion are discussed in the context of intertwined feedback loops between breast cancer cells and stromal cells. Moreover, the potential use of CCL5 and its receptor chemokine C-C motif receptor 5 (CCR5) as targets for preventing breast cancer metastasis is also reviewed.
类目[WOS]Chemistry, Medicinal
收录类别SCI
WOS记录号WOS:000362116500002
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228762
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
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Khalid, A,Wolfram, J,Ferrari, I,et al. Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2015,15(13):1063-1072.
APA Khalid, A.,Wolfram, J.,Ferrari, I.,Mu, CF.,Mai, JH.,...&赵宇亮.(2015).Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer.MINI-REVIEWS IN MEDICINAL CHEMISTRY,15(13),1063-1072.
MLA Khalid, A,et al."Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer".MINI-REVIEWS IN MEDICINAL CHEMISTRY 15.13(2015):1063-1072.
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