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Coculture with Low-Dose SWCNT Attenuates Bacterial Invasion and Inflammation in Human Enterocyte-like Caco-2 Cells
Chen HQ(陈汉清); Wang B(汪冰); Zheng LN(郑令娜); Zhou XY(周晓燕); Chai ZF(柴之芳); Zhao YL(赵宇亮); Feng WY(丰伟悦); Chen, HQ; Wang, BQ; Zhao, RF; Gao, D; Guan, M; Zheng, LN; Zhou, XY; Chai, ZF; Zhao, YL; Feng, WY
2015
发表期刊SMALL
卷号11期号:34页码:4366-4378
通讯作者丰伟悦
摘要Single walled carbon nanotubes (SWCNTs) have been shown to be highly effective against a wide range of bacteria. Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) infection is a well-known mediator to prolong hospitalization and initiate chronic inflammation, yet the biological effects of SWCNTs on the pathogen-infected enterocytes remain unclear. Herein, it is shown that the low-dose SWCNT treatment attenuates the human enterocyte-like Caco-2 cells from the damage of E. coli and S. aureus infection by suppressing NLRP3 inflammasome activation. The relatively low-dose (1 and 10 mu g mL(-1)) SWCNT treatments reduce the adhesion and invasion of E. coli and S. aureus to Caco-2 cells, increase the cell viability and proliferation, reduce the tight junction permeability, and restitute the integrity of cell surface microvilli structure, meanwhile has low cytotoxicity to the host cells. The low-dose SWCNT treatment further reduces the NLRP3-mediated IL-1 beta secretion in the infected cells. The results identify that a low-dose SWCNT treatment serves a protective function for the E. coli- and S. aureus-infected Caco-2 cells by negatively regulating mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation.
文章类型Article
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/smll.201500136
收录类别SCI ; EI ; CA
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000360852900014
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228742
专题院士
多学科研究中心
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GB/T 7714
Chen HQ,Wang B,Zheng LN,et al. Coculture with Low-Dose SWCNT Attenuates Bacterial Invasion and Inflammation in Human Enterocyte-like Caco-2 Cells[J]. SMALL,2015,11(34):4366-4378.
APA 陈汉清.,汪冰.,郑令娜.,周晓燕.,柴之芳.,...&Feng, WY.(2015).Coculture with Low-Dose SWCNT Attenuates Bacterial Invasion and Inflammation in Human Enterocyte-like Caco-2 Cells.SMALL,11(34),4366-4378.
MLA 陈汉清,et al."Coculture with Low-Dose SWCNT Attenuates Bacterial Invasion and Inflammation in Human Enterocyte-like Caco-2 Cells".SMALL 11.34(2015):4366-4378.
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