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A novel form of beta-strand assembly observed in A beta(33-42) adsorbed onto graphene
Wang XF(王晓峰); Wang, XF; Weber, JK; Liu, L; Dong, MD; Zhou, RH; Li, JY; Li JY(李敬源)
2015
发表期刊NANOSCALE
卷号7期号:37页码:15341-15348
通讯作者李敬源
文章类型Article
摘要Peptide assembly plays a seminal role in the fabrication of structural and functional architectures in cells. Characteristically, peptide assemblies are often dominated by beta-sheet structures, wherein component molecules are connected by backbone hydrogen bonds in a parallel or an antiparallel fashion. While beta-rich peptide scaffolds are implicated in an array of neurodegenerative diseases, the mechanisms by which toxic peptides assemble and mediate neuropathic effects are still poorly understood. In this work, we employ molecular dynamics simulations to study the adsorption and assembly of the fragment A beta(33-42) (taken from the A beta-42 peptide widely associated with Alzheimer's disease) on a graphene surface. We observe that such A beta(33-42) fragments, which are largely hydrophobic in character, readily adsorb onto the graphitic surface and coalesce into a well-structured, beta-strand-like assembly. Strikingly, the structure of such complex is quite unique: hydrophobic side-chains extend over the graphene surface and interact with adjacent peptides, yielding a well-defined mosaic of hydrophobic interaction patches. This ordered structure is markedly depleted of backbone hydrogen bonds. Hence, our simulation results reveal a distinct type of beta-strand assembly, maintained by hydrophobic side-chain interactions. Our finding suggests the backbone hydrogen bond is no longer crucial to the peptide assembly. Further studies concerning whether such beta-strand assembly can be realized in other peptide systems and in biologically-relevant contexts are certainly warranted.
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c5nr00555h
收录类别SCI ; EI ; CA ; MEDLINE
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000361675300042
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228721
专题多学科研究中心
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GB/T 7714
Wang XF,Wang, XF,Weber, JK,et al. A novel form of beta-strand assembly observed in A beta(33-42) adsorbed onto graphene[J]. NANOSCALE,2015,7(37):15341-15348.
APA 王晓峰.,Wang, XF.,Weber, JK.,Liu, L.,Dong, MD.,...&李敬源.(2015).A novel form of beta-strand assembly observed in A beta(33-42) adsorbed onto graphene.NANOSCALE,7(37),15341-15348.
MLA 王晓峰,et al."A novel form of beta-strand assembly observed in A beta(33-42) adsorbed onto graphene".NANOSCALE 7.37(2015):15341-15348.
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