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Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging
Yu J(余杰); Yin WY(尹文艳); Zheng XP(郑晓鹏); Tian G(田甘); Zhang X(张潇); Bo T(薄涛); Dong XH(董兴华); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yu, J; Yin, WY; Zheng, XP; Tian, G; Zhang, X; Bao, T; Dong, XH; Wang, ZL; Gu, ZJ; Ma, XY; Zhao, YL
2015
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume5Issue:9Pages:931-945
Corresponding Author尹文艳 ; 谷战军 ; 赵宇亮
SubtypeArticle
AbstractThe ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T-2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.
KeywordMagnetic target Photothermal therapy Magnetic resonance imaging Photoacoustic tomography imaging Theranostic
Subject AreaResearch & Experimental Medicine
DOI10.7150/thno.11802
Indexed BySCI
Language英语
WOS Research AreaMedicine, Research & Experimental
WOS SubjectResearch & Experimental Medicine
WOS IDWOS:000359472200002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228675
Collection多学科研究中心
Recommended Citation
GB/T 7714
Yu J,Yin WY,Zheng XP,et al. Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging[J]. THERANOSTICS,2015,5(9):931-945.
APA 余杰.,尹文艳.,郑晓鹏.,田甘.,张潇.,...&Zhao, YL.(2015).Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.THERANOSTICS,5(9),931-945.
MLA 余杰,et al."Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging".THERANOSTICS 5.9(2015):931-945.
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