Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging
Yu J(余杰); Yin WY(尹文艳); Zheng XP(郑晓鹏); Tian G(田甘); Zhang X(张潇); Bo T(薄涛); Dong XH(董兴华); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yu, J; Yin, WY; Zheng, XP; Tian, G; Zhang, X; Bao, T; Dong, XH; Wang, ZL; Gu, ZJ; Ma, XY; Zhao, YL
刊名THERANOSTICS
2015
卷号5期号:9页码:931-945
关键词Magnetic target Photothermal therapy Magnetic resonance imaging Photoacoustic tomography imaging Theranostic
学科分类Research & Experimental Medicine
DOI10.7150/thno.11802
通讯作者尹文艳 ; 谷战军 ; 赵宇亮
文章类型Article
英文摘要The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T-2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.
类目[WOS]Medicine, Research & Experimental
收录类别SCI
WOS记录号WOS:000359472200002
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228675
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Yu J,Yin WY,Zheng XP,et al. Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging[J]. THERANOSTICS,2015,5(9):931-945.
APA 余杰.,尹文艳.,郑晓鹏.,田甘.,张潇.,...&Zhao, YL.(2015).Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.THERANOSTICS,5(9),931-945.
MLA 余杰,et al."Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging".THERANOSTICS 5.9(2015):931-945.
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