Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia
Song, TB; Nie BB(聂彬彬); Nie, BB; Ma, ES; Che, J; Sun, SL; Wang, YL; Shan, BC; Liu, YW; Luo, SL; Ma, GL; Li, KF; Dan BC(单保慈)
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2015
卷号460期号:3页码:678-683
关键词Schizophrenia Rat Granger causality model Connectivity fMRI
学科分类Biochemistry & Molecular Biology; Biophysics
DOI10.1016/j.bbrc.2015.03.089
文章类型Article
英文摘要Schizophrenia is characterized by the disorder of "social brain". However, the alternation of connectivity density in brain areas of schizophrenia patients remains largely unknown. In this study, we successfully created a rat model of schizophrenia by the transfection of EGR3 gene into rat brain. We then investigated the connectivity density of schizophrenia susceptible regions in rat brain using functional magnetic resonance imaging (fMRI) in combination with multivariate Granger causality (GC) model. We found that the average signal strength in prefrontal lobe and hippocampus of schizophrenia model group was significantly higher than the control group. Bidirectional Granger causality connection was observed between hippocampus and thalamic in schizophrenia model group. Both connectivity density and Granger causality connection were changed in prefrontal lobe, hippocampus and thalamus after risperidone treatment. Our results indicated that fMRI in combination with GC connection analysis may be used as an important method in diagnosis of schizophrenia and evaluation the effect of antipsychotic treatment. These findings support the connectivity disorder hypothesis of schizophrenia and increase our understanding of the neural mechanisms of schizophrenia. (C) 2015 The Authors. Published by Elsevier Inc.
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
收录类别SCI
WOS记录号WOS:000359885300031
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228658
专题中国科学院高能物理研究所_核技术应用研究中心_期刊论文
中国科学院高能物理研究所_核技术应用研究中心
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Song, TB,Nie BB,Nie, BB,et al. Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,460(3):678-683.
APA Song, TB.,聂彬彬.,Nie, BB.,Ma, ES.,Che, J.,...&单保慈.(2015).Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,460(3),678-683.
MLA Song, TB,et al."Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460.3(2015):678-683.
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