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Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity
Wang LM(王黎明); Zhang TL(张田露); Li PY(李盼云); Huang WX(黄万霞); Tang JL(唐景龙); Wang PY(王鹏阳); Liu J(刘景); Yuan QX(袁清习); Bai R(白茹); Li B(李柏); Zhang K(张凯); Zhao YL(赵宇亮); Chen CY(陈春英); Wang, LM; Zhang, TL; Li, PY; Huang, WX; Tang, JL; Wang, PY; Liu, J; Yuan, QX; Bai, R; Li, B; Zhang, K; Zhao, YL; Chen, CY
2015
Source PublicationACS NANO
ISSN1936-0851
EISSN1936-086X
Volume9Issue:6Pages:6532-6547
Corresponding Author陈春英
SubtypeArticle
AbstractTo predict potential medical value or toxicity of nanoparticles (NPs), it is necessary to understand the chemical transformation during intracellular processes of NPs. However, it is a grand challenge to capture a high-resolution image of metallic NPs in a single cell and the chemical information on intracellular NPs. Here, by integrating synchrotron radiation-beam transmission X-ray microscopy (SR-TXM) and SR-X-ray absorption near edge structure (SR-XANES) spectroscopy, we successfully capture the 3D distribution of silver NPs (AgNPs) inside a single human monocyte (THP-1), associated with the chemical transformation of silver. The results reveal that the cytotoxicity of AgNPs is largely due to the chemical transformation of particulate silver from elemental silver (Ag-0)(n), to Ag+ ions and Ag-0-, then Ag-S- species. These results provide direct evidence in the long-lasting debate on whether the nanoscale or the ionic form dominates the cytotoxicity of silver nanoparticles. Further, the present approach provides an integrated strategy capable of exploring the chemical origins of cytotoxicity in metallic nanoparticles.
Keywordchemical origin nanotoxicity dynamic processes of intracellular nanoparticles chemical transformation AgNPs nano-CT
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science
DOI10.1021/acsnano.5b02483
Indexed BySCI ; EI ; CA
Language英语
WOS Research AreaChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science
WOS IDWOS:000356988500096
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228633
Collection多学科研究中心
实验物理中心
Recommended Citation
GB/T 7714
Wang LM,Zhang TL,Li PY,et al. Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity[J]. ACS NANO,2015,9(6):6532-6547.
APA 王黎明.,张田露.,李盼云.,黄万霞.,唐景龙.,...&Chen, CY.(2015).Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity.ACS NANO,9(6),6532-6547.
MLA 王黎明,et al."Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity".ACS NANO 9.6(2015):6532-6547.
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