Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity
Wang LM(王黎明); Zhang TL(张田露); Li PY(李盼云); Huang WX(黄万霞); Tang JL(唐景龙); Wang PY(王鹏阳); Liu J(刘景); Yuan QX(袁清习); Bai R(白茹); Li B(李柏); Zhang K(张凯); Zhao YL(赵宇亮); Chen CY(陈春英); Wang, LM; Zhang, TL; Li, PY; Huang, WX; Tang, JL; Wang, PY; Liu, J; Yuan, QX; Bai, R; Li, B; Zhang, K; Zhao, YL; Chen, CY
刊名ACS NANO
2015
卷号9期号:6页码:6532-6547
关键词chemical origin nanotoxicity dynamic processes of intracellular nanoparticles chemical transformation AgNPs nano-CT
学科分类Chemistry; Science & Technology - Other Topics; Materials Science
DOI10.1021/acsnano.5b02483
通讯作者陈春英
文章类型Article
英文摘要To predict potential medical value or toxicity of nanoparticles (NPs), it is necessary to understand the chemical transformation during intracellular processes of NPs. However, it is a grand challenge to capture a high-resolution image of metallic NPs in a single cell and the chemical information on intracellular NPs. Here, by integrating synchrotron radiation-beam transmission X-ray microscopy (SR-TXM) and SR-X-ray absorption near edge structure (SR-XANES) spectroscopy, we successfully capture the 3D distribution of silver NPs (AgNPs) inside a single human monocyte (THP-1), associated with the chemical transformation of silver. The results reveal that the cytotoxicity of AgNPs is largely due to the chemical transformation of particulate silver from elemental silver (Ag-0)(n), to Ag+ ions and Ag-0-, then Ag-S- species. These results provide direct evidence in the long-lasting debate on whether the nanoscale or the ionic form dominates the cytotoxicity of silver nanoparticles. Further, the present approach provides an integrated strategy capable of exploring the chemical origins of cytotoxicity in metallic nanoparticles.
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
收录类别SCI ; EI ; CA
WOS记录号WOS:000356988500096
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228633
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_实验物理中心
中国科学院高能物理研究所_多学科研究中心
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Wang LM,Zhang TL,Li PY,et al. Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity[J]. ACS NANO,2015,9(6):6532-6547.
APA 王黎明.,张田露.,李盼云.,黄万霞.,唐景龙.,...&Chen, CY.(2015).Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity.ACS NANO,9(6),6532-6547.
MLA 王黎明,et al."Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity".ACS NANO 9.6(2015):6532-6547.
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