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Silica-coated bismuth sulfide nanorods as multimodal contrast agents for a non-invasive visualization of the gastrointestinal tract
Zheng XP(郑晓鹏); Shi JX(施俊新); Tian G(田甘); Zhang X(张潇); Yin WY(尹文艳); Yan L(晏亮); Gu ZJ(谷战军); Zhao YL(赵宇亮); Zheng, XP; Shi, JX; Bu, Y; Tian, G; Zhang, X; Yin, WY; Gao, BF; Yang, ZY; Hu, ZB; Liu, XF; Yan, L; Gu, ZJ; Zhao, YL
2015
Source PublicationNANOSCALE
ISSN2040-3364
EISSN2040-3372
Volume7Issue:29Pages:12581-12591
Corresponding Author晏亮 ; 谷战军 ; 赵宇亮
SubtypeArticle
AbstractNon-invasive and real-time imaging of the gastrointestinal (GI) tract is particularly desirable for research and clinical studies of patients with symptoms arising from gastrointestinal diseases. Here, we designed and fabricated silica-coated bismuth sulfide nanorods (Bi2S3@SiO2 NRs) for a non-invasive spatial-temporally imaging of the GI tract. The Bi2S3 NRs were synthesized by a facile solvothermal method and then coated with a SiO2 layer to improve their biocompatibility and stability in the harsh environments of the GI tract, such as the stomach and the small intestine. Due to their strong X-ray- and near infrared-absorption abilities, we demonstrate that, following oral administration in mice, the Bi2S3@SiO2 NRs can be used as a dual-modal contrast agent for the real-time and non-invasive visualization of NRs distribution and the GI tract via both X-ray computed tomography (CT) and photoacoustic tomography (PAT) techniques. Importantly, integration of PAT with CT provides complementary information on anatomical details with high spatial resolution. In addition, we use Caenorhabditis Elegans (C. Elegans) as a simple model organism to investigate the biological response of Bi2S3@SiO2 NRs by oral administration. The results indicate that these NRs can pass through the GI tract of C. Elegans without inducing notable toxicological effects. The above results suggest that Bi2S3@SiO2 NRs pave an alternative way for the fabrication of multi-modal contrast agents which integrate CT and PAT modalities for a direct and non-invasive visualization of the GI tract with low toxicity.
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c5nr03068d
Indexed BySCI ; ADS ; EI ; CA ; MEDLINE
Language英语
WOS Research AreaChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS IDWOS:000358207700041
ADS Bibcode2015Nanos...712581Z
ADS URLhttps://ui.adsabs.harvard.edu/abs/2015Nanos...712581Z
ADS CITATIONShttps://ui.adsabs.harvard.edu/abs/2015Nanos...712581Z/citations
Citation statistics
Cited Times:4 [ADS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228587
Collection多学科研究中心
Recommended Citation
GB/T 7714
Zheng XP,Shi JX,Tian G,et al. Silica-coated bismuth sulfide nanorods as multimodal contrast agents for a non-invasive visualization of the gastrointestinal tract[J]. NANOSCALE,2015,7(29):12581-12591.
APA 郑晓鹏.,施俊新.,田甘.,张潇.,尹文艳.,...&Zhao, YL.(2015).Silica-coated bismuth sulfide nanorods as multimodal contrast agents for a non-invasive visualization of the gastrointestinal tract.NANOSCALE,7(29),12581-12591.
MLA 郑晓鹏,et al."Silica-coated bismuth sulfide nanorods as multimodal contrast agents for a non-invasive visualization of the gastrointestinal tract".NANOSCALE 7.29(2015):12581-12591.
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