Bio-inspired peptide-Au cluster applied for mercury (II) ions detection
Wang YL(王亚玲); Cui YY(崔岩岩); Liu R(刘茹); Gao FP(高福平); Gao J(高靓); Gao XY(高学云); Wang, YL; Cui, YY; Liu, R; Gao, FP; Gao, L; Gao, XY
刊名SCIENCE CHINA-CHEMISTRY
2015
卷号58期号:5页码:819-824
关键词peptide-Au cluster mercury (II) ions fluorescence detection
学科分类Chemistry
DOI10.1007/s11426-015-5379-9
通讯作者高学云
文章类型Article
英文摘要Mercury ion (Hg2+ ) pollution exists in water, soil, and food. By interacting with the thiol groups in protein, Hg2+ ions can accumulate in ways that cause serious damage to the central nervous system and threaten human health and natural environment. Undoubtedly, Hg2+ ion detection is a significant issue in environment and health monitoring. A variety of sensor platforms for Hg2+ ion detection based on organic molecules, DNA, oligonucleotides, inorganic materials, etc, have been reported. In this paper, an artificial peptide P-Hg, with a cluster bio-mineralize sequence (CCY) and a multi-charge hydrophilic sequence is designed as a template for the one-step synthesis of a peptide-Au cluster probe. Briefly: the peptide PHg in situ anchors Au ions to form a peptide-Au (I) intermediate and the reaction pH with NaOH is adjusted; after 12 h incubation at room temperature, the peptide PHg-Au nanocluster probe with red fluorescence is obtained. The probe has a super-small core size of approximately 1.26 nm and a maximum emission peak at 650 nm. The presence of Hg2+ ions cause the fluorescence of the probe to greatly decrease. Based on the differences in fluorescence intensity of the PHg-Au nanocluster in the absence and presence of Hg2+ ions, Hg2+ ions could be quantitatively detected in concentrations ranging from 5 nmol/L to 1 A mu mol/L. The limit of detection (LOD) is 7.5 nmol/L. Compared with some interference ions such as, K+, Mg2+, Ca2+, Pb2+, Ni2+, Fe3+, and Cu2+, the selectivity was excellent. The sensing of Hg2+ ion is not affected by the chelate agents: EDTA, which imparts a significant advantage in a range of applications. As a result, a simple, sensitive and selective fluorescent assay based on peptide PHg-Au cluster is developed for the detection of Hg2+ ions.
类目[WOS]Chemistry, Multidisciplinary
收录类别SCI ; EI ; CA
WOS记录号WOS:000354188900008
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228549
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Wang YL,Cui YY,Liu R,et al. Bio-inspired peptide-Au cluster applied for mercury (II) ions detection[J]. SCIENCE CHINA-CHEMISTRY,2015,58(5):819-824.
APA 王亚玲.,崔岩岩.,刘茹.,高福平.,高靓.,...&Gao, XY.(2015).Bio-inspired peptide-Au cluster applied for mercury (II) ions detection.SCIENCE CHINA-CHEMISTRY,58(5),819-824.
MLA 王亚玲,et al."Bio-inspired peptide-Au cluster applied for mercury (II) ions detection".SCIENCE CHINA-CHEMISTRY 58.5(2015):819-824.
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