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Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques
Wang B(汪冰); Feng WY(丰伟悦); Chai ZF(柴之芳); Zhao YL(赵宇亮); Wang, B; Feng, WY; Chai, ZF; Zhao, YL
2015
发表期刊SCIENCE CHINA-CHEMISTRY
卷号58期号:5页码:768-779
通讯作者丰伟悦
文章类型Review
摘要Understanding the interactions of nanomaterials (NMs) with biomolecules, organelles, cells, and organic tissues at the nano-bio interface can offer important information for their uptake, distribution, translocation, metabolism and degradation in vitro and in vivo, which can help to precisely tune and design "smart" NMs for biomedical applications. However, probing the interactions at the nano-bio interface, which generally requires dedicated analytical methods and tools, is remarkably complicated due to the dynamically changed nature of the nano-bio interface. Because of the advantages of high spatial resolution, high sensitivity, excellent accuracy, low matrix effects and non-destructiveness, synchrotron radiation (SR)-based analytical techniques have become extremely valuable tools. Herein, we present a comprehensive overview of SR-based techniques for the visualized study of NMs at cellular and subcellular interfaces and their transformation in vitro; the exploration of biodistribution, translocation, metabolism and degradation of NMs in vivo; and clarification of the molecular mechanisms of NMs' reactions with biomolecules. Rapid development of advanced light source means that in situ, real-time analysis of NMs at the nano-bio interface will be achieved.
关键词nano-bio interface synchrotron-radiation-based analytical techniques interaction
学科领域Chemistry
DOI10.1007/s11426-015-5394-x
收录类别SCI ; EI ; CA
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000354188900004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228548
专题院士
多学科研究中心
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GB/T 7714
Wang B,Feng WY,Chai ZF,et al. Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques[J]. SCIENCE CHINA-CHEMISTRY,2015,58(5):768-779.
APA 汪冰.,丰伟悦.,柴之芳.,赵宇亮.,Wang, B.,...&Zhao, YL.(2015).Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques.SCIENCE CHINA-CHEMISTRY,58(5),768-779.
MLA 汪冰,et al."Probing the interaction at nano-bio interface using synchrotron radiation-based analytical techniques".SCIENCE CHINA-CHEMISTRY 58.5(2015):768-779.
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