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Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence
Chen HQ(陈汉清); Wang B(汪冰); Feng WY(丰伟悦); Ou YH(欧阳宏); Chai ZF(柴之芳); Mi XL(秘晓林); Chen, HQ; Wang, B; Feng, WY; Du, W; Ouyang, H; Chai, ZF; Bi, XL
2015
发表期刊NANOTOXICOLOGY
卷号9期号:3页码:302-312
通讯作者丰伟悦
摘要The potential impacts of nanomaterials (NMs) on fetal development have attracted great concerns because of the increased potential exposure to NMs during pregnancy. Drosophila melanogaster oogenesis and developmental transitions may provide an attractive system to study the biological and environmental effects of NMs on the embryonic development. In this study, the effects of three types of magnetite (Fe3O4) nanoparticles (MNPs): UN-MNPs (pristine), CA-MNPs (citric acid modified) and APTS-MNPs (3-aminopropyltriethoxylsilane coated) on the development of Drosophila at 300 and 600 mu g/g dosage were studied. The uptake of MNPs by female and male flies caused obvious reduction in the female fecundity, and the developmental delay at the egg-pupae and pupae-adult transitions, especially in those treated by the positive APTS-MNPs. Further investigation demonstrates that the parental uptake of MNPs disturbs the oogenesis period, induces ovarian defect, reduces the length of eggs, decreases the number of nurse cells and delays egg chamber development, which may contribute to the decrease of fecundity of female Drosophila and the development delay of their offspring. Using the synchrotron radiation-based micro-X-ray fluorescence (SR-mu XRF), the dyshomeostasis of trace elements such as Fe, Ca and Cu along the anterior-posterior axis of the fertilized eggs was found, which may be an important reason for the development delay of Drosophila.
文章类型Article
关键词Developmental delay Drosophila melanogaster elements dyshomeostasis magnetite nanoparticles oogenesis
学科领域Science & Technology - Other Topics; Toxicology
DOI10.3109/17435390.2014.929189
收录类别SCI ; CA
WOS类目Nanoscience & Nanotechnology ; Toxicology
WOS记录号WOS:000354975400004
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228508
专题院士
多学科研究中心
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GB/T 7714
Chen HQ,Wang B,Feng WY,et al. Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence[J]. NANOTOXICOLOGY,2015,9(3):302-312.
APA 陈汉清.,汪冰.,丰伟悦.,欧阳宏.,柴之芳.,...&Bi, XL.(2015).Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence.NANOTOXICOLOGY,9(3),302-312.
MLA 陈汉清,et al."Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence".NANOTOXICOLOGY 9.3(2015):302-312.
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