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Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy
Zhang TC(张天冲); Yi FT(伊福廷); Wang B(王波); Liu J(刘静); Zhang XS(张新帅); Sun GJ(孙钢杰); Zhang, X; Tian, G; Yin, WY; Wang, LM; Zheng, XP; Yan, L; Li, JX; Su, HR; Chen, CY; Gu, ZJ; Zhao, YL
2015
发表期刊ADVANCED FUNCTIONAL MATERIALS
卷号25期号:20页码:3049-3056
通讯作者田甘 ; 谷战军 ; 赵宇亮
文章类型Article
摘要NaYbF4:Tm@NaYF4:Yb/Er upconversion nanoparticles are synthesized and then integrated with light-sensitive nitric oxide (NO) donors (Roussin's black salt) to construct a novel near-infrared (NIR)-triggered on-demand NO delivery platform. This nanocompound can absorb 980 nm NIR photons, convert them into higher energy photons and then transfer the energy to the NO donors, resulting in an efficient release of NO. By manipulating the output power of the 980-nm NIR light, NO-concentration-dependent biological effects for cancer therapy can be fine-tuned, which is investigated and confirmed in vitro. High concentrations of NO can directly kill cancer cells and low concentrations of NO can act as a potent P-glycoprotein (P-gp) modulator to overcome multi-drug resistance (MDR) if combined with chemotherapy.
关键词upconversion nanoparticles nitric oxide energy transfer dose-dependent biological effect multi-drug resistance reversal
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/adfm.201404402
收录类别SCI ; EI ; CA
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000355125400011
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被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228483
专题多学科研究中心
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GB/T 7714
Zhang TC,Yi FT,Wang B,et al. Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(20):3049-3056.
APA 张天冲.,伊福廷.,王波.,刘静.,张新帅.,...&Zhao, YL.(2015).Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy.ADVANCED FUNCTIONAL MATERIALS,25(20),3049-3056.
MLA 张天冲,et al."Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy".ADVANCED FUNCTIONAL MATERIALS 25.20(2015):3049-3056.
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