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Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients
Xu, J; Cheng, YQ; Lai, AY; Lv, ZP; Campbell, RAA; Yu, HJ; Luo, CR; Shan, B; Xu, L; Xu, XF; Dan BC(单保慈)
2015
发表期刊JOURNAL OF IMMUNOLOGY RESEARCH
卷号2015页码:920718
文章类型Article
摘要This study explores the relationship between autoantibodies and brain density reduction in SLE patients without major neuropsychiatric manifestation (NPSLE). Ninety-five NPSLE patients without obvious cerebral deficits, as determined by conventional MRI, as well as 89 control subjects, underwent high-resolution structural MRI. Whole-brain density of grey matter (GMD) and white matter (WMD) were calculated for each individual, and correlations between the brain density, symptom severity, immunosuppressive agent (ISA), and autoantibody levels were assessed. The GMD and WMD of the SLE group decreased compared to controls. GMD was negatively associated with SLE activity. The WMD of patients who received ISA treatment were higher than that in the patients who did not. The WMD of patients with anticardiolipin (ACL) or anti-SSB/La antibodies was lower than in patients without these antibodies, while the GMD was lower in patients with anti-SMor anti-U1RNP antibodies. Thus, obvious brain atrophy can occur very early even before the development of significant symptoms and specific autoantibodies might contribute to the reduction of GMD or WMD in NPSLE patients. However, ISAs showed protective effects in minimizing GMD and WMD reduction. The presence of these specific autoantibodies might help identify early brain damage in NPSLE patients.
学科领域Immunology
DOI10.1155/2015/920718
收录类别SCI
WOS类目Immunology
WOS记录号WOS:000355549900001
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228480
专题核技术应用研究中心
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Xu, J,Cheng, YQ,Lai, AY,et al. Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2015,2015:920718.
APA Xu, J.,Cheng, YQ.,Lai, AY.,Lv, ZP.,Campbell, RAA.,...&单保慈.(2015).Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients.JOURNAL OF IMMUNOLOGY RESEARCH,2015,920718.
MLA Xu, J,et al."Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients".JOURNAL OF IMMUNOLOGY RESEARCH 2015(2015):920718.
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