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Ultrasmall [Cu-64] Cu Nanoclusters for Targeting Orthotopic Lung Tumors Using Accurate Positron Emission Tomography Imaging
Gao FP(高福平); Yang WJ(杨文江); Xue JQ(薛井泉); Gao J(高靓); Liu R(刘茹); Wang YL(王亚玲); He X(何潇); Zhao LN(赵丽娜); Zhao YL(赵宇亮); Chai ZF(柴之芳); Gao XY(高学云); Gao, FP; Cai, PJ; Yang, WJ; Xue, JQ; Gao, L; Liu, R; Wang, YL; Zhao, YW; He, X; Zhao, LN; Huang, GD; Wu, FS; Zhao, YL; Chai, ZF; Gao, XY
2015
Source PublicationACS NANO
ISSN1936-0851
EISSN1936-086X
Volume9Issue:5Pages:4976-4986
Corresponding Author高学云
SubtypeArticle
AbstractPositron emission tomography (PET) imaging has received special attention owing to its higher sensitivity, temporal resolution, and unlimited tissue penetration. The development of tracers that target specific molecules is therefore essential for the development and utility of clinically relevant PET procedures. However, Cu-64 as a PET imaging agent generally has been introduced into biomaterials through macrocyclic chelators, which may lead to the misinterpretation of PET imaging results due to the detachment and transchelation of Cu-64. In this study, we have developed ultrasmall chelator-free radioactive [Cu-64]Cu nanoclusters using bovine serum albumin (BSA) as a scaffold for PET imaging in an orthotopic lung cancer model. We preconjugated the tumor target peptide luteinizing hormone releasing hormone (LHRH) to BSA molecules to prepare [(64)Ct]Cu-NC@BSA-LHRH. The prepared [Cu-64]Cu nanoclusters showed high radiolabeling stability, ultrasmall size, and rapid deposition and diffusion into tumor, as well as predominantly renal clearance. [Cu-64]Cu-NC@BSA-LHRH showed 4 times higher tumor uptake compared with that of [Cu-64]Cu-NC@BSA by analyzing the Cu-64 radioactivity of tissues via gamma counting. The PET imaging using [Cu-64]Cu nanoclusters as tracers showed more sensitive, accurate, and deep penetration imaging of orthotopic lung cancer in vivo compared with near-infrared fluorescence imaging. The nanoclusters provide biomedical research tools for PET molecular imaging.
Keyword(64)copper nanoclusters positron emission tomography imaging orthotopic lung tumor tumor target luteinizing hormone releasing hormone
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science
DOI10.1021/nn507130k
Indexed BySCI ; EI ; CA
Language英语
WOS Research AreaChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science
WOS IDWOS:000355383000033
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228474
Collection院士
多学科研究中心
核技术应用研究中心
Recommended Citation
GB/T 7714
Gao FP,Yang WJ,Xue JQ,et al. Ultrasmall [Cu-64] Cu Nanoclusters for Targeting Orthotopic Lung Tumors Using Accurate Positron Emission Tomography Imaging[J]. ACS NANO,2015,9(5):4976-4986.
APA 高福平.,杨文江.,薛井泉.,高靓.,刘茹.,...&Gao, XY.(2015).Ultrasmall [Cu-64] Cu Nanoclusters for Targeting Orthotopic Lung Tumors Using Accurate Positron Emission Tomography Imaging.ACS NANO,9(5),4976-4986.
MLA 高福平,et al."Ultrasmall [Cu-64] Cu Nanoclusters for Targeting Orthotopic Lung Tumors Using Accurate Positron Emission Tomography Imaging".ACS NANO 9.5(2015):4976-4986.
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