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Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle
Qin YP(秦艳平); Chen J(陈俊); Bi Y(毕颖); Xu XH(徐小晗); Zhou H(周晖); Hu Y(胡毅); Zhao YL(赵宇亮); Chai ZF(柴之芳); Qin, YP; Chen, J; Bi, Y; Xu, XH; Zhou, H; Gao, JM; Hu, Y; Zhao, YL; Chai, ZF
2015
发表期刊ACTA BIOMATERIALIA
卷号17页码:201-209
通讯作者陈俊 ; 胡毅
文章类型Article
摘要Stimuli-responsive drug delivery systems have been developed to enhance the tumor-targeting drug transportation and minimize the severe side effects along with the chemotherapy. In this study, a near-infrared (NIR) light triggered drug delivery system was developed based on the amphiphilic chitosan derivative-coated single-wall carbon nanotubes (CNT) encapsulated in the thermo/pH sensitive nano-gel (CS/PNIPAAm@CNT). The PEG diacrylate (Mw = 250 Da) was applied in the present work to tune the nanoparticles with the phase transition temperature at similar to 38 degrees C, which was an attempt to match the prerequisite for the in vivo applications. Owing to the pi-pi stacking, hydrophobic interaction and the opportunity of Schiff-base formation between chitosan and doxorubicin (DOX), the nanoparticles possessed a relative high drug loading capacity (similar to 43%). The DOX loaded CS/PNIPAAm@CNT released DOX faster at 40 degrees C than at 25 degrees C, meanwhile faster at pH 5.0 in comparison with that at pH 7.4. Moreover, the rapid and repetitive release of DOX was observed when the DOX-loaded CS/PNIPAAm@CNT was irradiated under NIR light. Furthermore, DOX-loaded CS/PNIPAAm@CNT upon NIR irradiation showed significantly greater cytotoxicity in HeLa cells owing to NIR-triggered increase in temperature and enhanced DOX release. Confocal laser scanning microscopy (CLSM) was utilized to demonstrate the enhanced cell uptake of the as prepared nanoparticles and the faster drug release under the NIR irradiation and lower pH. All the results suggest that multifunctional DOX-loaded CS/PNIPAAm@CNT nanocomposite is a promising therapeutic nanocarrier for intracellular drug delivery with great potential for targeted cancer therapy. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
关键词Near-infrared light Photothermal effect Carbon nanotube pH/temperature sensitivity Intracellular drug delivery
学科领域Engineering; Materials Science
DOI10.1016/j.actbio.2015.01.026
收录类别SCI
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号WOS:000352665700020
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228328
专题院士
多学科研究中心
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GB/T 7714
Qin YP,Chen J,Bi Y,et al. Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle[J]. ACTA BIOMATERIALIA,2015,17:201-209.
APA 秦艳平.,陈俊.,毕颖.,徐小晗.,周晖.,...&Chai, ZF.(2015).Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle.ACTA BIOMATERIALIA,17,201-209.
MLA 秦艳平,et al."Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle".ACTA BIOMATERIALIA 17(2015):201-209.
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