IHEP OpenIR  > 院士
Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry
Zheng LN(郑令娜); Wang M(王萌); Zhao LC(赵磊超); Sun BY(孙宝云); Wang B(汪冰); Chen HQ(陈汉清); Zhao YL(赵宇亮); Chai ZF(柴之芳); 丰伟悦Zheng, LN; Wang, M; Zhao, LC; Sun, BY; Wang, B; Chen, HQ; Zhao, YL; Chai, ZF; Feng, WY
2015
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN1618-2642
EISSN1618-2650
Volume407Issue:9Pages:2383-2391
Corresponding Author丰伟悦
SubtypeArticle
AbstractCisplatin is a commonly used chemotherapeutic drug in cancer treatment, whereas Gd@C-82(OH)(22) is a new nanomaterial anti-tumor agent. In this study, we determined intracellular Gd@C-82(OH)(22) and cisplatin after treatment of Hela and 16HBE cells by single cell inductively coupled plasma-mass spectrometry (SC-ICP-MS), which could provide quantitative information at a single-cell level. The cell digestion method validated the accuracy of the SC-ICP-MS. The concentrations of Gd@C-82(OH)(22) and cisplatin in cells at different exposure times and doses were studied. The SC-ICP-MS is a promising complement to available methods for single cell analysis and is anticipated to be applied further to biomedical research.
KeywordCisplatin Gd@C-82(OH)(22) Single cell ICP-MS Quantitative analysis
Subject AreaBiochemistry & Molecular Biology; Chemistry
DOI10.1007/s00216-014-8422-3
Indexed BySCI ; EI ; CA
Language英语
WOS Research AreaBiochemical Research Methods ; Chemistry, Analytical
WOS SubjectBiochemistry & Molecular Biology ; Chemistry
WOS IDWOS:000351510300005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228246
Collection院士
多学科研究中心
Recommended Citation
GB/T 7714
Zheng LN,Wang M,Zhao LC,et al. Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2015,407(9):2383-2391.
APA 郑令娜.,王萌.,赵磊超.,孙宝云.,汪冰.,...&Feng, WY.(2015).Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,407(9),2383-2391.
MLA 郑令娜,et al."Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 407.9(2015):2383-2391.
Files in This Item:
File Name/Size DocType Version Access License
180.pdf(771KB)期刊论文作者接受稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[郑令娜]'s Articles
[王萌]'s Articles
[赵磊超]'s Articles
Baidu academic
Similar articles in Baidu academic
[郑令娜]'s Articles
[王萌]'s Articles
[赵磊超]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[郑令娜]'s Articles
[王萌]'s Articles
[赵磊超]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.