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Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry
Zheng LN(郑令娜); Wang M(王萌); Zhao LC(赵磊超); Sun BY(孙宝云); Wang B(汪冰); Chen HQ(陈汉清); Zhao YL(赵宇亮); Chai ZF(柴之芳); 丰伟悦Zheng, LN; Wang, M; Zhao, LC; Sun, BY; Wang, B; Chen, HQ; Zhao, YL; Chai, ZF; Feng, WY
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2015
卷号407期号:9页码:2383-2391
关键词Cisplatin Gd@C-82(OH)(22) Single cell ICP-MS Quantitative analysis
学科分类Biochemistry & Molecular Biology; Chemistry
DOI10.1007/s00216-014-8422-3
通讯作者丰伟悦
文章类型Article
英文摘要Cisplatin is a commonly used chemotherapeutic drug in cancer treatment, whereas Gd@C-82(OH)(22) is a new nanomaterial anti-tumor agent. In this study, we determined intracellular Gd@C-82(OH)(22) and cisplatin after treatment of Hela and 16HBE cells by single cell inductively coupled plasma-mass spectrometry (SC-ICP-MS), which could provide quantitative information at a single-cell level. The cell digestion method validated the accuracy of the SC-ICP-MS. The concentrations of Gd@C-82(OH)(22) and cisplatin in cells at different exposure times and doses were studied. The SC-ICP-MS is a promising complement to available methods for single cell analysis and is anticipated to be applied further to biomedical research.
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
收录类别SCI ; EI ; CA
WOS记录号WOS:000351510300005
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228246
专题院士_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Zheng LN,Wang M,Zhao LC,et al. Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2015,407(9):2383-2391.
APA 郑令娜.,王萌.,赵磊超.,孙宝云.,汪冰.,...&Feng, WY.(2015).Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,407(9),2383-2391.
MLA 郑令娜,et al."Quantitative analysis of Gd@C-82(OH)(22) and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 407.9(2015):2383-2391.
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