IHEP OpenIR
A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors
Zhang H(张衡); Zhang, H; de Vries, RP; Tzarum, N; Zhu, XY; Yu, WL; McBride, R; Paulson, JC; Wilson, IA
2015
Source PublicationCELL HOST & MICROBE
ISSN1931-3128
EISSN1934-6069
Volume17Issue:3Pages:377-384
SubtypeArticle
AbstractRecent avian-origin H10N8 influenza A viruses that have infected humans pose a potential pandemic threat. Alterations in the viral surface glycoprotein, hemagglutinin (HA), typically are required for influenza A viruses to cross the species barrier for adaptation to a new host, but whether H10N8 contains adaptations supporting human infection remains incompletely understood. We investigated whether H10N8 HA can bind human receptors. Sialoside glycan microarray analysis showed that the H10 HA retains a strong preference for avian receptor analogs and negligible binding to human receptor analogs. Crystal structures of H10 HA with avian and human receptor analogs revealed the basis for preferential recognition of avian-like receptors. Furthermore, introduction of mutations into the H10 receptor-binding site (RBS) known to convert other HA subtypes from avian to human receptor specificity failed to switch preference to human receptors. Collectively, these findings suggest that the current H10N8 human isolates are poorly adapted for efficient human-to-human transmission.
Subject AreaMicrobiology; Parasitology; Virology
DOI10.1016/j.chom.2015.02.006
Indexed BySCI ; MEDLINE
Language英语
WOS Research AreaMicrobiology ; Parasitology ; Virology
WOS SubjectMicrobiology ; Parasitology ; Virology
WOS IDWOS:000350979800016
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228230
Collection中国科学院高能物理研究所
Recommended Citation
GB/T 7714
Zhang H,Zhang, H,de Vries, RP,et al. A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors[J]. CELL HOST & MICROBE,2015,17(3):377-384.
APA 张衡.,Zhang, H.,de Vries, RP.,Tzarum, N.,Zhu, XY.,...&Wilson, IA.(2015).A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors.CELL HOST & MICROBE,17(3),377-384.
MLA 张衡,et al."A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors".CELL HOST & MICROBE 17.3(2015):377-384.
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