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A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors
Zhang H(张衡); Zhang, H; de Vries, RP; Tzarum, N; Zhu, XY; Yu, WL; McBride, R; Paulson, JC; Wilson, IA
2015
发表期刊CELL HOST & MICROBE
卷号17期号:3页码:377-384
摘要Recent avian-origin H10N8 influenza A viruses that have infected humans pose a potential pandemic threat. Alterations in the viral surface glycoprotein, hemagglutinin (HA), typically are required for influenza A viruses to cross the species barrier for adaptation to a new host, but whether H10N8 contains adaptations supporting human infection remains incompletely understood. We investigated whether H10N8 HA can bind human receptors. Sialoside glycan microarray analysis showed that the H10 HA retains a strong preference for avian receptor analogs and negligible binding to human receptor analogs. Crystal structures of H10 HA with avian and human receptor analogs revealed the basis for preferential recognition of avian-like receptors. Furthermore, introduction of mutations into the H10 receptor-binding site (RBS) known to convert other HA subtypes from avian to human receptor specificity failed to switch preference to human receptors. Collectively, these findings suggest that the current H10N8 human isolates are poorly adapted for efficient human-to-human transmission.
文章类型Article
学科领域Microbiology; Parasitology; Virology
DOI10.1016/j.chom.2015.02.006
收录类别SCI ; MEDLINE
WOS类目Microbiology ; Parasitology ; Virology
WOS记录号WOS:000350979800016
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228230
专题多学科研究中心
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Zhang H,Zhang, H,de Vries, RP,et al. A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors[J]. CELL HOST & MICROBE,2015,17(3):377-384.
APA 张衡.,Zhang, H.,de Vries, RP.,Tzarum, N.,Zhu, XY.,...&Wilson, IA.(2015).A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors.CELL HOST & MICROBE,17(3),377-384.
MLA 张衡,et al."A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors".CELL HOST & MICROBE 17.3(2015):377-384.
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