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Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo
Zhao F(赵峰); Yan L(晏亮); Wang B(汪冰); Zhao YL(赵宇亮); Zhao, F; Meng, H; Yan, L; Wang, B; Zhao, YL
2015
发表期刊SCIENCE BULLETIN
卷号60期号:1页码:3-20
通讯作者赵宇亮
摘要The chemical and biological mechanisms of life processes mostly consist of multistep and programmed processes at nanoscale levels. Interestingly enough, cell, the basic functional unit and platform that maintains life processes, is composed of various organelles fulfilling sophisticated functions through the precise control on the biomolecules (e.g., proteins, phospholipid, nucleic acid and ions) in a spatial dimension of nanoscale sizes. Thus, understanding of the activities of manufactured nanoscale materials including their interaction with biological systems is of great significance in chemistry, materials science, life science, medicine, environmental science and toxicology. In this brief review, we summarized the recent advances in nanotoxicological chemistry through the dissection of pivotal factors (primarily focusing on dose and nanosurface chemistry) in determining nanomaterial-induced biological/toxic responses with particular emphasis on the nanomaterial bioaccumulation (and interaction organs or target organs) at intact animal level. Due to the volume of manufacture and material application, we deliberately discussed carbon nanotubes, metal/metal oxide nanomaterials and quantum dots, severing as representative material types to illustrate the impact of dose and nanosurface chemistry in these toxicological scenarios. Finally, we have also delineated the grand challenges in this field in a conceptual framework of nanotoxicological chemistry. It is noted that this review is a part of our persistent endeavor of building the systematic knowledge framework for toxicological properties of engineered nanomaterials.
文章类型Review
关键词Bioaccumulation Toxicity Targeted organs Carbon nanotubes Metal nanomaterials Quantum dots
学科领域Science & Technology - Other Topics
DOI10.1007/s11434-014-0700-0
收录类别SCI ; CA
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000347924400003
引用统计
被引频次:61[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228198
专题多学科研究中心
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GB/T 7714
Zhao F,Yan L,Wang B,et al. Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo[J]. SCIENCE BULLETIN,2015,60(1):3-20.
APA 赵峰.,晏亮.,汪冰.,赵宇亮.,Zhao, F.,...&Zhao, YL.(2015).Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo.SCIENCE BULLETIN,60(1),3-20.
MLA 赵峰,et al."Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo".SCIENCE BULLETIN 60.1(2015):3-20.
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