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Quantifying the total ionic release from nanoparticles after particle-cell contact
He X(何潇); Li YY(李媛媛); Ma YH(马宇辉); 张鹏(多); Ding YY(丁雅韵); Zhang J(张静); Zhao YL(赵宇亮); Chai ZF(柴之芳); Zhang ZY(张智勇); He, X; Pan, YY; Zhang, JZ; Li, YY; Ma, YH; Zhang, P; Ding, YY; Zhang, J; Wu, ZQ; Zhao, YL; Chai, ZF; Zhang, ZY
Corresponding Author张智勇
AbstractIn order to assess the potential hazards of nanoparticles (NPs) releasing, better knowledge about their toxicity to microbes is required. However, it remains controversial whether NPs could exert particlespecific toxicity. In this study, the toxic impacts of four kinds of rare earth oxides (REO) NPs (La2O3, CeO2, Gd2O3, and Yb2O3) on gram-negative Escherichia coli (E. coli) pBR322 were examined. The results indicate that all the tested NPs possessed cytotoxicity against E. coli. To evaluate the ion-related toxicity of REO NPs, the NPs dissolution in the presence of test organisms was quantitatively measured using X-ray absorption fine structure (XAFS) spectroscopy. Our results suggest that NPs-cell contact could facilitate the dissolution of NPs, and the additional ionic release at the particle-cell interface might result in a substantial increase in the ion-related toxicities towards the test organisms. Therefore, the ion-related toxicity of NPs might be grossly underestimated if the additional dissolution of NPs caused by particle-cell contact was overlooked, further leading to a false interpretation of particle-specific toxicity. To the best of our knowledge, this is the first determination of the total NPs dissolution after particle-cell contact. These findings are helpful to advance mechanistic understanding of the toxicity exerted by dissolvable metal-based NPs. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordDissolution Ion-related toxicity Particle-cell contact X-ray absorption fine spectroscopy
Subject AreaEnvironmental Sciences & Ecology
Indexed BySCI ; CA
WOS Research AreaEnvironmental Sciences
WOS SubjectEnvironmental Sciences & Ecology
WOS IDWOS:000347583900023
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Document Type期刊论文
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GB/T 7714
He X,Li YY,Ma YH,et al. Quantifying the total ionic release from nanoparticles after particle-cell contact[J]. ENVIRONMENTAL POLLUTION,2015,196:194-200.
APA 何潇.,李媛媛.,马宇辉.,张鹏.,丁雅韵.,...&Zhang, ZY.(2015).Quantifying the total ionic release from nanoparticles after particle-cell contact.ENVIRONMENTAL POLLUTION,196,194-200.
MLA 何潇,et al."Quantifying the total ionic release from nanoparticles after particle-cell contact".ENVIRONMENTAL POLLUTION 196(2015):194-200.
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