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Crystal structure of the Locusta migratoria odorant binding protein
Zheng, JG; Li, JR; Han, L; Wang, Y; Wu, W; Qi, XX; Tao, Y; Zhang, L; Zhang, ZD; Chen, ZZ; Tao Y(陶冶)
2015
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷号456期号:3页码:737-742
文章类型Article
摘要Locusta migratoria (Lmig) causes enormous losses to agricultural products, especially because it often infests the world with great swarms as locust plagues. Locusts find their plant hosts on which they feed through their olfactory system, in which odorant binding proteins (OBPs) play an important role. Previous study indicated that the amino acid sequences of LmigOBP showed low similarity to OBPs from other insect orders and we speculated that it might perform unique binding behavior. Here, we solved the first LmigOBP1 structure at 1.65 angstrom, which is a monomer in solution and disulfide bonds play a key role in maintaining its function. We show that LmigOBP1 possesses a unique seventh a-helix, which is located at the surface with strong interactions with the LmigOBP1 scaffold consisting of other six a-helices. Moreover, the seventh a-helix forms a wall of an "L" shaped internal hydrophobic cavity to accommodate linear ligands, which is consistent with the binding experiments. We also demonstrate that the ligand-binding pocket in LmigOBP1 is greatly different from that in the closest homologs mosquito OBPs. Taken together, this study provides a structural basis for designing small inhibitors to control locust. (C) 2014 Elsevier Inc. All rights reserved.
关键词Locusta migratoria Odorant binding protein Odorant perception Crystal structure Ligand binding mechanism
学科领域Biochemistry & Molecular Biology; Biophysics
DOI10.1016/j.bbrc.2014.12.048
收录类别SCI
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000348973300006
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228138
专题多学科研究中心
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GB/T 7714
Zheng, JG,Li, JR,Han, L,et al. Crystal structure of the Locusta migratoria odorant binding protein[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,456(3):737-742.
APA Zheng, JG.,Li, JR.,Han, L.,Wang, Y.,Wu, W.,...&陶冶.(2015).Crystal structure of the Locusta migratoria odorant binding protein.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,456(3),737-742.
MLA Zheng, JG,et al."Crystal structure of the Locusta migratoria odorant binding protein".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 456.3(2015):737-742.
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