IHEP OpenIR
Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans
Cong WS(丛文姝); Cong, WS; Wang, P; Qu, Y; Tang, JL; Bai, R; Zhao, YL; Chen, CY; Bi, XL; Zhao YL(赵宇亮); Mi XL(秘晓林)
2015
Source PublicationBIOMATERIALS
ISSN0142-9612
EISSN1878-5905
Volume42Pages:78-86
Corresponding Author秘晓林
SubtypeArticle
AbstractFullerene derivatives have attracted extensive attention in biomedical fields and polyhydroxyl fullerene (fullerenol), a water-soluble fullerene derivative, is demonstrated as a powerful antioxidant. To further assess their anti-aging and anti-stress potential, we employed Caenorhabditis elegans (C elegans) as a model organism to evaluate the effects of fullerenol on the growth, development, behavior and anti-stress ability in vivo. The data show that fullerenol has no obviously toxic effect on nematodes and can delay C elegans aging progress under normal condition. Further studies demonstrate that fullerenol attenuates endogenous levels of reactive oxygen species and provides protection to C elegans under stress conditions by up-regulating stress-related genes in a DAF-16 depend manner and improving lifespan. In summary, our data suggest that fullerenol might be a safe and reasonable anti-aging candidate with great potential in vivo. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordFullerenol Anti-aging Caenorhabditis elegans Lifespan DAF-16 Insulin/IGF-1 pathway
Subject AreaEngineering; Materials Science
DOI10.1016/j.biomaterials.2014.11.048
Indexed BySCI ; EI ; CA
Language英语
WOS Research AreaEngineering, Biomedical ; Materials Science, Biomaterials
WOS SubjectEngineering ; Materials Science
WOS IDWOS:000348883700008
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/228121
Collection中国科学院高能物理研究所
Recommended Citation
GB/T 7714
Cong WS,Cong, WS,Wang, P,et al. Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans[J]. BIOMATERIALS,2015,42:78-86.
APA 丛文姝.,Cong, WS.,Wang, P.,Qu, Y.,Tang, JL.,...&秘晓林.(2015).Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans.BIOMATERIALS,42,78-86.
MLA 丛文姝,et al."Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans".BIOMATERIALS 42(2015):78-86.
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