Fine-Tuned H-Ferritin Nanocage with Multiple Gold Clusters as NearInfrared Kidney Specific Targeting Nanoprobe
Sun, CJ; Yuan, Y; Xu ZH(徐钟河); Li JY(李敬源); Xu, ZH; Ji, TJ; Tian, YH; Wu, S; Lei, JL; Li, JY; Gao, N; Nie, GJ
刊名BIOCONJUGATE CHEMISTRY
2015
卷号26期号:2页码:193-196
学科分类Biochemistry & Molecular Biology; Chemistry
DOI10.1021/bc5005284
通讯作者李敬源
文章类型Article
英文摘要When stabilized and functionalized by biomolecules, noble metal (such as gold and silver) cluster-based hybrid nanocomposites have shown great promise for biomedical applications, due to their unique physiochemical properties originating from the inorganic elements and specific functionality and biocompatibility from their biological components. Although certain promise for bioimaging, biosensing, and biomimetic catalysis has been demonstrated, it is still a great challenge to integrate the defined functionality of the biomolecules with enhanced or novel physiochemical properties of the metal clusters, under control at the molecular level. Herein, based on molecular dynamics simulation of a gold (Au) cluster assembly, we designed near-infrared (NIR) fluorescent hybrid nanocomposites with multiple Au clusters within an apo H-ferritin (HFt) nanocage. The fluorescence quantum yield of near-infrared (NIR) Au-HFt is about 63.4% and the emission peak is 810 nm. The NIR Au-HFt is one of the first native protein-guided Au cluster-based nanomaterials for in vivo biowindow imaging. In vivo fluorescent imaging and quantification of Au element confirmed that Au-HFt not only retained the kidney targeting properties of HFt well (about 10 times higher Au concentration in kidney than in liver and spleen, the most common organs for nanoparticle accumulation), but also gained strong NIR imaging capability for live animals. The NIR Au-HFt showed powerful tissue penetrating ability, strong fluorescent efficiency, and excellent kidney targeting specificity. These results thus open new opportunities for kidney disease imaging and theranostic applications.
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
收录类别SCI
WOS记录号WOS:000349807200004
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228108
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Sun, CJ,Yuan, Y,Xu ZH,et al. Fine-Tuned H-Ferritin Nanocage with Multiple Gold Clusters as NearInfrared Kidney Specific Targeting Nanoprobe[J]. BIOCONJUGATE CHEMISTRY,2015,26(2):193-196.
APA Sun, CJ.,Yuan, Y.,徐钟河.,李敬源.,Xu, ZH.,...&Nie, GJ.(2015).Fine-Tuned H-Ferritin Nanocage with Multiple Gold Clusters as NearInfrared Kidney Specific Targeting Nanoprobe.BIOCONJUGATE CHEMISTRY,26(2),193-196.
MLA Sun, CJ,et al."Fine-Tuned H-Ferritin Nanocage with Multiple Gold Clusters as NearInfrared Kidney Specific Targeting Nanoprobe".BIOCONJUGATE CHEMISTRY 26.2(2015):193-196.
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